Agustí C, Ferrán F, Gea J, Picado C
Department of Pneumology, Hospital Clinic, Faculty of Medicine, Barcelona, Spain.
Arch Intern Med. 1991 Feb;151(2):380. doi: 10.1001/archinte.1991.00400020124025.
We report a case of bilateral hearing loss in a patient treated with intravenous erythromycin lactobionate. The ototoxic reaction occurred despite the patient's having normal renal and hepatic function and the fact that serum erythromycin levels were within the predicted normal range. In addition to hearing loss, a marked labyrinthic hyporreflexia was also observed. Hearing loss improved after the treatment was discontinued, but labyrinthic abnormalities persisted suggesting that erythromycin had caused a permanent vestibular damage.
我们报告了一例接受静脉注射乳糖酸红霉素治疗的患者出现双侧听力丧失的病例。尽管该患者肾功能和肝功能正常，且血清红霉素水平在预测的正常范围内，但仍发生了耳毒性反应。除听力丧失外，还观察到明显的迷路反射减退。停药后听力丧失有所改善，但迷路异常持续存在，提示红霉素已造成永久性前庭损伤。
