Scuola Superiore Sant'Anna, Pisa, Italy.
Mini Rev Med Chem. 2009 Oct;9(11):1251-61. doi: 10.2174/138955709789878132.
Carbon nanotubes are widely used for biomedical applications as intracellular transporters of biomolecules, due to their high propensity to cross cell membranes. In this review we summarize the recent advancement in the functionalization of carbon nanotubes, focusing particular attention on the chemistry involved in the preparation of nanovectors for drug delivery systems, and on the physical and chemical properties that affect cellular up-take and biodistribution phenomena.
碳纳米管由于其高穿透细胞膜的倾向,被广泛用作生物分子的细胞内转运器,用于生物医学应用。在这篇综述中,我们总结了碳纳米管功能化的最新进展,特别关注用于药物传递系统的纳米载体制备中涉及的化学,以及影响细胞摄取和生物分布现象的物理和化学性质。