Klumpp Cédric, Kostarelos Kostas, Prato Maurizio, Bianco Alberto
Institute of Molecular and Cellular Biology, UPR 9021 CNRS, 15 Rue René Descartes, 67084 Strasbourg, France.
Biochim Biophys Acta. 2006 Mar;1758(3):404-12. doi: 10.1016/j.bbamem.2005.10.008. Epub 2005 Nov 9.
Functionalized carbon nanotubes (f-CNT) are emerging as a new family of nanovectors for the delivery of different types of therapeutic molecules. The application of CNT in the field of carrier-mediated delivery has become possible after the recent discovery of their capacity to penetrate into the cells. CNT can be loaded with active molecules by forming stable covalent bonds or supramolecular assemblies based on noncovalent interactions. Once the cargos are carried into various cells, tissues and organs they are able to express their biological function. In this review, we will describe the potential of f-CNT to deliver different types of therapeutic molecules.
功能化碳纳米管（f-CNT）正成为用于递送不同类型治疗性分子的新型纳米载体家族。在最近发现碳纳米管具有穿透细胞的能力之后，其在载体介导递送领域的应用成为可能。碳纳米管可以通过形成稳定的共价键或基于非共价相互作用的超分子组装体来负载活性分子。一旦货物被携带到各种细胞、组织和器官中，它们就能够发挥其生物学功能。在这篇综述中，我们将描述功能化碳纳米管递送不同类型治疗性分子的潜力。
