Queen's University, Psychology, Kingston, Ontario K7L 3N6, Canada.
J Sex Med. 2010 Feb;7(2 Pt 2):858-72. doi: 10.1111/j.1743-6109.2009.01599.x. Epub 2009 Nov 19.
Phosphodiesterase type 5 inhibitors (PDE5), such as sildenafil, tadalafil, and vardenafil, have revolutionized the treatment of erectile dysfunction. Few successes, in contrast, have been reported for the use of these agents in treatment of sexual arousal problems in women.
To review research examining efficacy of PDE5 in women, critique the methods and models employed, and integrate the findings within a broader, gender-specific understanding of female sexual response.
A conceptual and methodological review of all published studies examining PDE5 efficacy in female samples.
Study methods, populations, outcome measures, study results.
A total of 16 studies were reviewed. Studies using self-reported measures of sexual functioning showed mixed results whereas studies examining physiological effects of PDE5 on genital vasocongestion consistently report significant effects on genital sexual response.
The lack of efficacy of PDE5 treatment in women is likely attributable to gender differences in the concordance between physiological and psychological components of sexual response. Discordance between genital and subjective measures of sexual response in women may be augmented by PDE5 effects on genital vasocongestion in some populations, rendering successful treatment unlikely via pharmacological treatment alone.
磷酸二酯酶 5 抑制剂（PDE5），如西地那非、他达拉非和伐地那非，已经彻底改变了勃起功能障碍的治疗方法。相比之下，这些药物在治疗女性性欲问题方面的应用却鲜有成功的报道。
回顾研究评估 PDE5 在女性中的疗效，评价所采用的方法和模型，并将研究结果纳入更广泛的、针对女性的性反应的性别特异性理解中。
对所有研究 PDE5 在女性样本中的疗效的已发表研究进行概念和方法学的回顾。
研究方法、人群、结局指标、研究结果。
共综述了 16 项研究。使用自我报告的性行为功能测量的研究结果不一，而研究 PDE5 对生殖器血管充血的生理影响的研究则一致报告 PDE5 对生殖器性反应有显著影响。
女性 PDE5 治疗效果不佳可能归因于性反应的生理和心理成分之间的一致性存在性别差异。在某些人群中，PDE5 对生殖器血管充血的影响可能会增加生殖器和主观性行为反应之间的不匹配，从而使仅通过药物治疗难以取得成功。
