Department of Surgical Specialities, Azienda Ospedaliera Universitaria G. Martino, Via Consolare Valeria, Messina, Italy.
Br J Dermatol. 2010 Mar;162(3):681-3. doi: 10.1111/j.1365-2133.2009.09557.x. Epub 2009 Nov 24.
FOXE1 is a candidate tumour suppressor gene at human chromosome locus 9q22. This is a region frequently lost in squamous cell cancer.
To assess the influence of FOXE1 variations on genetic susceptibility to cutaneous squamous cell carcinoma (SCC).
We performed mutational analysis of FOXE1 in 320 DNA samples isolated from 60 SCC specimens, 60 adjacent histologically normal skin samples and 200 blood samples.
No somatic mutations were evident. Instead the polyalanine tract showed marked variation in its length between samples from patients with SCC and normal controls.
These results imply that another tumour suppressor gene at this locus may be more important than FOXE1 in skin carcinogenesis and suggest that variation in the FOXE1 polyalanine tract length predisposes to cutaneous SCC.
FOXE1 是人类染色体 9q22 上的候选肿瘤抑制基因。这是鳞状细胞癌中经常缺失的区域。
评估 FOXE1 变异对皮肤鳞状细胞癌 (SCC) 遗传易感性的影响。
我们对 60 个 SCC 标本、60 个相邻组织学正常皮肤标本和 200 个血液标本中的 320 个 DNA 样本进行了 FOXE1 突变分析。
没有明显的体细胞突变。相反，多聚丙氨酸链在 SCC 患者和正常对照组的样本之间其长度有明显的差异。
这些结果表明，该基因座上的另一个肿瘤抑制基因可能比 FOXE1 更重要，在皮肤癌变中，并且表明 FOXE1 多聚丙氨酸链长度的变异易患皮肤 SCC。
