Kimura Shioko
Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
J Thyroid Res. 2011;2011:710213. doi: 10.4061/2011/710213. Epub 2011 Apr 28.
Homeodomain, forkhead domain, and paired domain-containing transcription factors play a major role in development, tissue-specific gene expression, and tissue homeostasis in organs where they are expressed. Recently, their roles in stem cell and cancer biology are emerging. In the thyroid, NKX2-1, FOXE1, and PAX8 transcription factors are responsible for thyroid organogenesis and expression of thyroid-specific genes critical for thyroid hormone synthesis. In contrast to their known roles in gene regulation, thyroid development and homeostasis, their involvement in stem cell, and/or cancer biology are still elusive. In order to further understand the nature of thyroid cancer, it is critical to determine their roles in thyroid cancer.
含同源结构域、叉头结构域和配对结构域的转录因子在其表达的器官的发育、组织特异性基因表达和组织稳态中发挥着主要作用。最近，它们在干细胞生物学和癌症生物学中的作用正在显现。在甲状腺中，NKX2-1、FOXE1和PAX8转录因子负责甲状腺器官发生以及对甲状腺激素合成至关重要的甲状腺特异性基因的表达。与它们在基因调控、甲状腺发育和稳态中的已知作用相反，它们在干细胞生物学和/或癌症生物学中的参与情况仍不清楚。为了进一步了解甲状腺癌的本质，确定它们在甲状腺癌中的作用至关重要。
