Mittal Rahul, Sharma Saroj, Chhibber Sanjay, Aggarwal Sudhir, Gupta Varsha, Harjai Kusum
Children's Hospital Los Angeles, Los Angeles, CA, USA.
FEMS Immunol Med Microbiol. 2010 Mar;58(2):237-43. doi: 10.1111/j.1574-695X.2009.00627.x. Epub 2009 Nov 28.
Pseudomonas aeruginosa is one of the leading causes of catheter-associated urinary tract infections (UTIs), associated with high mortality and morbidity. In this study, 50 P. aeruginosa isolates from urine of patients with UTIs were serotyped according to the international antigenic typing system. The majority of the isolates (34%) belonged to serogroup O11, whereas 22%, 10%, 8%, 8%, 6%, 6%, 4% and 2% strains belonged to serogroups OII, O6, O1, O8, O7/8, O3, O4 and O15, respectively. Uroisolates belonging to serogroup O11 were strong biofilm producers, whereas serogroup O6 were weak biofilm producers. O11 serogroup uroisolates also showed increased adhesion to uroepithelium and elaborated higher levels of all the virulence factors. A strong correlation between serotype, in vitro biofilm formation and elaboration of virulence factors was observed. The data suggest that differences in virulence potential according to serotype should be taken into account to design effective preventive strategies against P. aeruginosa-induced UTIs.
铜绿假单胞菌是导管相关尿路感染（UTI）的主要病因之一，与高死亡率和高发病率相关。在本研究中，根据国际抗原分型系统对从UTI患者尿液中分离出的50株铜绿假单胞菌进行了血清分型。大多数分离株（34%）属于O11血清群，而22%、10%、8%、8%、6%、6%、4%和2%的菌株分别属于OII、O6、O1、O8、O7/8、O3、O4和O15血清群。属于O11血清群的尿道分离株是强生物膜产生菌，而O6血清群的是弱生物膜产生菌。O11血清群尿道分离株对尿道上皮的黏附性也增强，并且所有毒力因子的水平更高。观察到血清型、体外生物膜形成与毒力因子表达之间存在很强的相关性。数据表明，在设计针对铜绿假单胞菌引起的UTI的有效预防策略时，应考虑血清型导致的毒力潜力差异。
