Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, Nei-Hu, Taipei, Taiwan.
J Biomed Sci. 2009 Nov 25;16(1):106. doi: 10.1186/1423-0127-16-106.
Co-administration of dextromethorphan (DM) with morphine during pregnancy and throughout lactation has been found to reduce morphine physical dependence and tolerance in rat offspring. No evidence was presented, however, for the effect of DM co-administered with morphine during pregnancy on morphine-induced reward and behavioral sensitization (possibly related to the potential to induce morphine addiction) in morphine-exposed offspring. Conditioned place preference and locomotor activity tests revealed that the p60 male offspring of chronic morphine-treated female rats were more vulnerable to morphine-induced reward and behavioral sensitization. The administration of a low dose of morphine (1 mg/kg, i.p.) in these male offspring also increased the dopamine and serotonin turnover rates in the nucleus accumbens, which implied that they were more sensitive to morphine. Co-administration of DM with morphine in the dams prevented this adverse effect of morphine in the offspring rats. Thus, DM may possibly have a great potential in the prevention of higher vulnerability to psychological dependence of morphine in the offspring of morphine-addicted mothers.
在怀孕期间和哺乳期同时给予右美沙芬（DM）和吗啡会减少大鼠后代对吗啡的身体依赖和耐受。然而，并没有证据表明在怀孕期间同时给予 DM 和吗啡会对吗啡暴露的后代的吗啡引起的奖赏和行为敏感化（可能与诱导吗啡成瘾的潜力有关）产生影响。条件性位置偏好和运动活性测试表明，慢性吗啡处理的雌性大鼠的 p60 雄性后代更容易受到吗啡引起的奖赏和行为敏感化的影响。在这些雄性后代中给予低剂量吗啡（1mg/kg，ip）也会增加伏隔核中的多巴胺和 5-羟色胺周转率，这意味着它们对吗啡更敏感。在母体中同时给予 DM 和吗啡可预防吗啡对后代大鼠的这种不良影响。因此，DM 可能在预防吗啡成瘾母亲的后代对吗啡的心理依赖方面具有巨大潜力。
