Manjunath M K, Annam V, Suresh D R
Department of ENT-Head and Neck Surgery, Sree Siddhartha Medical College, Tumkur, Karnataka, India.
J Laryngol Otol. 2010 Mar;124(3):315-7. doi: 10.1017/S0022215109991721. Epub 2009 Nov 23.
Laryngeal and hypopharyngeal cancer is a multifactorial disease caused by various carcinogens such as tobacco, alcohol and viruses. Likewise, oxidative stress is known to cause aberrations in the cell membrane and DNA, leading to cancer. We conducted this prospective study in order to evaluate the level of oxidative stress in laryngeal and hypopharyngeal cancer patients.
Fifty patients with laryngeal and hypopharyngeal cancer and 40 control subjects were selected. Serum malondialdehyde concentrations and ferric reducing antioxidant power were assessed, in order to evaluate oxidative stress. Results were analysed by Student's t-test.
Malondialdehyde levels were significantly higher and ferric reducing antioxidant power lower in the cancer patients, compared with the controls, indicating higher oxidative stress in the former. There was no statistically significant difference in malondialdehyde concentration or ferric reducing antioxidant power, comparing patients with versus without neck secondaries, and patients with early stage versus late stage tumours.
Oxidative stress may have a role to play in the initiation of laryngeal and hypopharyngeal cancers, especially in patients with other risk factors such as tobacco and alcohol use.
喉癌和下咽癌是一种由烟草、酒精和病毒等多种致癌物引起的多因素疾病。同样，氧化应激已知会导致细胞膜和DNA异常，进而引发癌症。我们开展这项前瞻性研究，以评估喉癌和下咽癌患者的氧化应激水平。
选取50例喉癌和下咽癌患者及40例对照者。评估血清丙二醛浓度和铁还原抗氧化能力，以评估氧化应激。结果采用学生t检验进行分析。
与对照组相比，癌症患者的丙二醛水平显著更高，铁还原抗氧化能力更低，表明前者的氧化应激更高。比较有颈部转移与无颈部转移的患者，以及早期与晚期肿瘤患者，丙二醛浓度或铁还原抗氧化能力无统计学显著差异。
氧化应激可能在喉癌和下咽癌的发生中起作用，尤其是在有烟草和酒精使用等其他风险因素的患者中。
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