Ramezani Ali, Ghandi Narges, Akhyani Maryam, Daneshpazhooh Maryam, Naraghi Zahra S, Chams-Davatchi Cheyda
Autoimmune Bullous Diseases Research Center, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Dermatol Online J. 2009 Sep 15;15(9):9.
Vaginal involvement in pemphigus vulgaris has previously been described. In all those cases a pelvic examination was needed to explore the lesions. We describe a patient with pemphigus vulgaris who had pemphigus erosions on a prolapsed uterus (i.e., on the everted surface of vagina). The patient had widespread lesions of pemphigus in other mucosal and cutaneous sites. Biopsy, antibodies against desmoglein 1 and 3, and direct and indirect immunofluorescence were confirming. The erosions on the prolapsed uterus were resistant to treatment; other mucosal and cutaneous lesions responded rapidly to prednisolone and azathioprine. After lowering the dose of prednisolone the patient was referred to a gynecologist for a vaginal hysterectomy. This case was unique because her vaginal lesions could be easily examined and followed.
寻常型天疱疮累及阴道此前已有报道。在所有这些病例中，均需进行盆腔检查以探查病变。我们描述了一名患有寻常型天疱疮的患者，其脱垂子宫（即阴道外翻表面）出现了天疱疮糜烂。该患者在其他黏膜和皮肤部位有广泛的天疱疮病变。活检、抗桥粒芯糖蛋白1和3抗体以及直接和间接免疫荧光检查均得以确诊。脱垂子宫上的糜烂对治疗有抵抗性；其他黏膜和皮肤病变对泼尼松龙和硫唑嘌呤反应迅速。在降低泼尼松龙剂量后，该患者被转诊至妇科医生处进行阴道子宫切除术。此病例独特之处在于其阴道病变易于检查和随访。
