2005 年 3 月至 2007 年 2 月在柬埔寨金边市开展的基于医院的轮状病毒腹泻监测。

Hospital-based surveillance for rotavirus diarrhoea in Phnom Penh, Cambodia, March 2005 through February 2007.

机构信息

Division of Translational Research, International Vaccine Institute, Seoul, Republic of Korea.

出版信息

Vaccine. 2009 Nov 20;27 Suppl 5:F81-4. doi: 10.1016/j.vaccine.2009.08.085.

DOI:10.1016/j.vaccine.2009.08.085

PMID:19931726

Abstract

Globally rotavirus is the most common cause of severe gastroenteritis in children. From March 2005 through February 2007, a prospective hospital-based surveillance study was conducted at a national hospital in Phnom Penh, Cambodia, to estimate the burden of rotavirus hospitalizations among children aged <5 years old and to determine strain patterns. Children with diarrhoea underwent standard clinical evaluations. Parents were interviewed for demographic and family information. Faecal specimens were tested for rotavirus by enzyme immunoassay (EIA) and positive specimens were further characterized. Of 2817 hospitalized children with diarrhoea, 56% (n=1278) were positive for rotavirus antigen. The G1P[8] strain was the most common genotype (53%) followed by G2P[4] (10%). The findings suggest a need for improved prevention and control programs for rotavirus diarrhoea in Cambodia.

摘要

全球范围内，轮状病毒是导致儿童严重肠胃炎的最常见原因。从 2005 年 3 月至 2007 年 2 月，柬埔寨金边的一家国家医院开展了一项基于医院的前瞻性监测研究，旨在评估 5 岁以下儿童因轮状病毒住院的负担，并确定病毒株模式。患有腹泻的儿童接受了标准的临床评估。对家长进行了人口统计学和家庭信息的访谈。采用酶联免疫吸附试验（EIA）检测粪便标本中的轮状病毒抗原，对阳性标本进行进一步鉴定。在 2817 例因腹泻住院的儿童中，56%（n=1278）轮状病毒抗原检测呈阳性。最常见的基因型是 G1P[8]（53%），其次是 G2P[4]（10%）。研究结果表明，柬埔寨有必要改善轮状病毒腹泻的预防和控制计划。