植物乳杆菌 CtsR 应激反应调控基因的鉴定。
Characterization of the CtsR stress response regulon in Lactobacillus plantarum.
机构信息
Department of Biomedical Sciences, University of Foggia, Viale L. Pinto, 71100 Foggia, Italy.
出版信息
J Bacteriol. 2010 Feb;192(3):896-900. doi: 10.1128/JB.01122-09. Epub 2009 Nov 20.
Abstract
Lactobacillus plantarum ctsR was characterized. ctsR was found to be cotranscribed with clpC and induced in response to various abiotic stresses. ctsR deletion conferred a heat-sensitive phenotype with peculiar cell morphological features. The transcriptional pattern of putative CtsR regulon genes was examined in the Delta ctsR mutant. Direct CtsR-dependent regulation was demonstrated by DNA-binding assays using recombinant CtsR and the promoters of the ctsR-clpC operon and hsp1.
摘要
植物乳杆菌 ctsR 的特性。ctsR 与 clpC 共转录，并对各种非生物胁迫作出响应。ctsR 缺失赋予了热敏感表型和独特的细胞形态特征。在 Delta ctsR 突变体中检查了假定 CtsR 调节子基因的转录模式。通过使用重组 CtsR 和 ctsR-clpC 操纵子和 hsp1 的启动子进行 DNA 结合测定，证明了直接的 CtsR 依赖性调节。
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