Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA, USA.
JAMA. 2009 Nov 25;302(20):2214-21. doi: 10.1001/jama.2009.1738.
Chronic pain is a major contributor to disability in older adults; however, the potential role of chronic pain as a risk factor for falls is poorly understood.
To determine whether chronic musculoskeletal pain is associated with an increased occurrence of falls in a cohort of community-living older adults.
DESIGN, SETTING, AND PARTICIPANTS: The Maintenance of Balance, Independent Living, Intellect, and Zest in the Elderly (MOBILIZE) Boston Study is a population-based longitudinal study of falls involving 749 adults aged 70 years and older. Participants were enrolled from September 2005 through January 2008.
Participants recorded falls on monthly calendar postcards mailed to the study center during an 18-month period.
There were 1029 falls reported during the follow-up. A report of 2 or more locations of musculoskeletal pain at baseline was associated with greater occurrence of falls. The age-adjusted rates of falls per person-year were 1.18 (95% confidence interval [CI], 1.13-1.23) for the 300 participants with 2 or more sites of joint pain, 0.90 (95% CI, 0.87-0.92) for the 181 participants with single-site pain, and 0.78 (95% CI, 0.74-0.81) for the 267 participants with no joint pain. Similarly, more severe or disabling pain at baseline was associated with higher fall rates (P < .05). The association persisted after adjusting for multiple confounders and fall risk factors. The greatest risk for falls was observed in persons who had 2 or more pain sites (adjusted rate ratio [RR], 1.53; 95% CI, 1.17-1.99), and those in the highest tertiles of pain severity (adjusted RR, 1.53; 95% CI, 1.12-2.08) and pain interference with activities (adjusted RR, 1.53; 95%CI, 1.15-2.05), compared with their peers with no pain or those in the lowest tertiles of pain scores.
Chronic pain measured according to number of locations, severity, or pain interference with daily activities was associated with greater risk of falls in older adults.
慢性疼痛是导致老年人残疾的主要原因之一;然而,慢性疼痛作为跌倒风险因素的潜在作用尚未得到充分理解。
确定慢性肌肉骨骼疼痛是否与社区居住的老年人群体中跌倒的发生率增加有关。
设计、地点和参与者:维持平衡、独立生活、智力和老年人活力(MOBILIZE)波士顿研究是一项基于人群的跌倒纵向研究,涉及 749 名 70 岁及以上的成年人。参与者于 2005 年 9 月至 2008 年 1 月期间招募。
参与者在 18 个月的时间内通过每月邮寄到研究中心的日历明信卡记录跌倒情况。
在随访期间报告了 1029 次跌倒。基线时报告有 2 个或更多部位的肌肉骨骼疼痛与跌倒发生率增加相关。按年龄调整后的每人每年跌倒率为:有 2 个或更多关节疼痛部位的 300 名参与者为 1.18(95%置信区间[CI],1.13-1.23);有单个疼痛部位的 181 名参与者为 0.90(95%CI,0.87-0.92);无关节疼痛的 267 名参与者为 0.78(95%CI,0.74-0.81)。同样,基线时更严重或更具致残性的疼痛与更高的跌倒率相关(P<.05)。在调整了多种混杂因素和跌倒风险因素后,这种关联仍然存在。在有 2 个或更多疼痛部位的人群中(调整后的比率比[RR],1.53;95%CI,1.17-1.99),以及在疼痛严重程度最高三分位数(调整后的 RR,1.53;95%CI,1.12-2.08)和疼痛对活动的干扰最高三分位数(调整后的 RR,1.53;95%CI,1.15-2.05)的人群中,跌倒风险最高,与无疼痛或疼痛评分最低三分位数的同龄人相比。
根据疼痛部位数量、严重程度或疼痛对日常活动的干扰程度测量的慢性疼痛与老年人跌倒风险增加相关。