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大麻与多种药物联用导致急性意识模糊和无法行走而住院

Cannabis and Polypharmacy Leading to Hospitalization for Acute Confusion and Inability to Ambulate.

作者信息

McKnight Lucas, Widman Joshua J

机构信息

Internal Medicine, The Ohio State University Wexner Medical Center and Nationwide Children's Hospital, Columbus, USA.

Hospital Medicine, The Ohio State University Wexner Medical Center, Columbus, USA.

出版信息

Cureus. 2025 Mar 12;17(3):e80481. doi: 10.7759/cureus.80481. eCollection 2025 Mar.

DOI:10.7759/cureus.80481
PMID:40225514
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11991439/
Abstract

Inability to ambulate is a common issue for which an Emergency Department (ED) may request inpatient admission to the hospital. Frequent contributing factors include advanced age, spinal stenosis, osteoarthritis, deconditioning, and polypharmacy. We present an interesting case of a patient admitted due to inability to ambulate who had a significant acute decline in function coincident with the introduction of gabapentin in the setting of heavy tetrahydrocannabinol (THC) use.

摘要

无法行走是急诊科可能会要求患者住院治疗的常见问题。常见的促成因素包括高龄、椎管狭窄、骨关节炎、身体机能减退和多种药物联用。我们报告了一例有趣的病例，一名因无法行走而入院的患者，在大量使用四氢大麻酚（THC）的情况下开始服用加巴喷丁后，其功能急剧急性下降。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/084f/11991439/3d2a297038af/cureus-0017-00000080481-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/084f/11991439/20b823654379/cureus-0017-00000080481-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/084f/11991439/3d2a297038af/cureus-0017-00000080481-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/084f/11991439/20b823654379/cureus-0017-00000080481-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/084f/11991439/3d2a297038af/cureus-0017-00000080481-i02.jpg

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本文引用的文献

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The Impact of Recreational Cannabis Legalization on Cannabis Use and Associated Outcomes: A Systematic Review.娱乐用大麻合法化对大麻使用及相关结果的影响：一项系统评价
Subst Abuse. 2023 May 9;17:11782218231172054. doi: 10.1177/11782218231172054. eCollection 2023.
2
Measuring Within-Individual Cannabis Reduction in Clinical Trials: A Review of the Methodological Challenges.在临床试验中测量个体内大麻使用量的减少：方法学挑战综述
Curr Addict Rep. 2019 Dec;6(4):429-436. doi: 10.1007/s40429-019-00290-y. Epub 2019 Nov 19.
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Drug interactions with cannabinoids.
与大麻素的药物相互作用。
CMAJ. 2020 Mar 2;192(9):E206. doi: 10.1503/cmaj.191097.
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Gabapentin for post-operative pain management - a systematic review with meta-analyses and trial sequential analyses.加巴喷丁用于术后疼痛管理——一项包含荟萃分析和试验序贯分析的系统评价
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Polypharmacy and falls in the elderly: a literature review.老年人的多重用药与跌倒：文献综述
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JAMA. 2009 Nov 25;302(20):2214-21. doi: 10.1001/jama.2009.1738.
8
The adverse health effects of cannabis use: what are they, and what are their implications for policy?大麻使用对健康的不良影响：它们是什么，以及对政策有什么影响？
Int J Drug Policy. 2009 Nov;20(6):458-66. doi: 10.1016/j.drugpo.2009.02.013. Epub 2009 Apr 10.
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Abstinence and moderate use goals in the treatment of marijuana dependence.大麻依赖治疗中的禁欲和适度使用目标。
Addiction. 2006 Nov;101(11):1589-97. doi: 10.1111/j.1360-0443.2006.01609.x.