TP53基因多态性可实现犬传染性性病肿瘤的基因亚分组。
TP53 Polymorphisms allow for genetic sub-grouping of the canine transmissible venereal tumor.
作者信息
Sánchez-Servín Abel, Martínez Simón, Córdova-Alarcon Emilio, Fajardo Raúl
机构信息
Centro de Investigación y de Estudios Avanzados en Salud Animal, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Carretera de cuota Toluca-Atlacomulco, Kilómetro 15.5 C.P. 50200, Toluca Edo, México.
出版信息
J Vet Sci. 2009 Dec;10(4):353-5. doi: 10.4142/jvs.2009.10.4.353.
The canine transmissible venereal tumor (CTVT) is found mainly in dogs' sexual organs. Currently, it is widely accepted that all samples of CTVT show similar histopathological characteristics and share common genetic alterations. Despite the common genetic origin of CTVT, mutations in the P53 gene have been reported. In this study, we proposed that tumor samples can be genetically grouped using this gene. The presence of different subgroups of CTVT was determined in Mexican dogs using the TP53 gene sequence in CTVT samples. Four new polymorphisms were found and therefore, the CTVT samples were classified in five subgroups.
犬传染性性病肿瘤（CTVT）主要出现在犬类的性器官中。目前，人们普遍认为所有CTVT样本都显示出相似的组织病理学特征并具有共同的基因改变。尽管CTVT有共同的基因起源，但已有报道称其P53基因存在突变。在本研究中，我们提出可以使用该基因对肿瘤样本进行基因分组。利用CTVT样本中的TP53基因序列，确定了墨西哥犬中CTVT不同亚组的存在情况。发现了四个新的多态性，因此，CTVT样本被分为五个亚组。
Zotero 插件