Li Guo-Liang, Qiao Zhi-Mei, Han Ji-Sheng, Luo Fei
Department of Anesthesiology, Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, China.
Neuroreport. 2010 Jan 6;21(1):2-7. doi: 10.1097/WNR.0b013e32832e0c5a.
It has been proposed that high-frequency oscillations (HFOs) and underlying conventional somatosensory-evoked potentials (SEPs) have different brain origins. To further explore the neural mechanism of HFOs, we recorded the SEPs responding to high-intensity electrical stimulation applied to the hind paw of conscious, freely moving rats. We also investigated the effect of systemic morphine on HFOs and the conventional SEPs. HFOs after high-intensity electrical stimulation showed a widespread distribution in frontal and temporal regions of the brain. The amplitude of HFOs was significantly decreased by systemic morphine, whereas the primary conventional SEP components remained unaffected. The different changes in HFOs and primary SEP components after systemic morphine administration provided further evidence for the hypothesis that HFOs and underlying conventional SEP components have different origins.
有人提出高频振荡（HFOs）和潜在的传统体感诱发电位（SEPs）具有不同的脑起源。为了进一步探索HFOs的神经机制，我们记录了清醒、自由活动大鼠后爪接受高强度电刺激时的SEP。我们还研究了全身应用吗啡对HFOs和传统SEP的影响。高强度电刺激后的HFOs在大脑额叶和颞叶区域广泛分布。全身应用吗啡可使HFOs的振幅显著降低，而主要的传统SEP成分未受影响。全身应用吗啡后HFOs和主要SEP成分的不同变化为HFOs和潜在的传统SEP成分具有不同起源这一假说提供了进一步的证据。
