Vitreous, Retina, and Macula Consultants of New York, New York, New York 10022, USA.
Retina. 2009 Oct;29(9):1213-7. doi: 10.1097/IAE.0b013e3181b32d27.
To explore the incidence of complications after bilateral same-day intravitreal injections of antivascular endothelial growth factor pharmacotherapies in this retrospective interventional case series.
An electronic review of billing records was performed to identify all bilateral same-day intravitreal antivascular endothelial growth factor injections performed within a single group retina practice between January 6, 2006 and June 1, 2009. The charts were reviewed to identify the complications of endophthalmitis, intraocular inflammation, retinal tear, and retinal detachment.
A total of 1,534 bilateral intravitreal injections (326 bevacizumab and 1,208 ranibizumab: 3,068 injections total) were performed in 367 patients. Three complications were identified. Two cases of unilateral culture-proven endophthalmitis occurred after bilateral intravitreal ranibizumab, and one case of unilateral acute intraocular inflammation occurred after bilateral intravitreal bevacizumab. In all three of these eyes, visual acuity returned to its preinjection level. No cases of retinal tear or retinal detachment were identified. The incidence of culture-proven endophthalmitis was 0.065%, and the incidence of acute intraocular inflammation was 0.033%.
The complication rates after bilateral same-day intravitreal antivascular endothelial growth factor injections seem to be similar to those after unilateral injections. Severe acute intraocular inflammation can occur unilaterally after same-day bilateral injections of bevacizumab.
通过回顾性干预性病例系列研究，探讨双眼同一天玻璃体内注射抗血管内皮生长因子药物后发生并发症的情况。
对 2006 年 1 月 6 日至 2009 年 6 月 1 日期间，在一家视网膜专业诊所接受双眼同一天玻璃体内抗血管内皮生长因子注射的所有患者的计费记录进行电子审查。对病历进行回顾，以确定眼内炎、眼内炎症、视网膜裂孔和视网膜脱离等并发症的发生情况。
共对 367 例患者的 1534 例双眼玻璃体内注射（326 例贝伐单抗和 1208 例雷珠单抗：共 3068 例注射）进行了分析。发现了 3 种并发症。2 例双侧玻璃体内雷珠单抗注射后发生单侧培养证实的眼内炎，1 例双侧玻璃体内贝伐单抗注射后发生单侧急性眼内炎症。所有这 3 只眼睛的视力均恢复到注射前的水平。未发现视网膜裂孔或视网膜脱离的病例。培养证实的眼内炎发生率为 0.065%，急性眼内炎症发生率为 0.033%。
双眼同一天玻璃体内注射抗血管内皮生长因子后发生并发症的几率似乎与单侧注射相似。贝伐单抗同一天双侧注射后可单侧发生严重急性眼内炎症。
