比较新型共焦扫描激光检眼镜算法与光学相干断层扫描在黄斑厚度和体积测量中的应用。

Comparison of a novel confocal scanning laser ophthalmoscopy algorithm with optical coherence tomography in measurement of macular thickness and volume.

机构信息

Jacobs Retina Center, University of California San Diego, Shiley Eye Center, La Jolla, California 92037, USA.

出版信息

Retina. 2009 Oct;29(9):1328-34. doi: 10.1097/IAE.0b013e3181ac7d30.

DOI:10.1097/IAE.0b013e3181ac7d30

PMID:19934823

Abstract

PURPOSE

To evaluate macular thickness and volume measurements using a novel Heidelberg Retinal Tomograph (HRT3) algorithm and to compare the results with optical coherence tomography (StratusOCT).

METHODS

This was a prospective, comparative, clinical noninterventional study. Fifty-two eyes were examined using both methods: 16 normal eyes, 12 eyes with diabetic macular edema (DME), and 24 eyes with age-related macular degeneration (AMD). The HRT3 macular thickness and volume were compared with those from the StratusOCT automated software. In addition, the distances between the retinal surface and the base of subretinal pathologic changes were measured using the StratusOCT manual-caliper technique and were compared with the HRT3 measurements in AMD eyes.

RESULTS

No statistically significant difference in macular thickness and volume measurements was observed between the two methods for normal (P = 0.89 and P = 0.33, respectively) and DME eyes (P = 0.86 and P = 0.31, respectively). However, in AMD eyes, the differences in both measurements were statistically significant between the two methods (P < 0.0001 and P < 0.0001, respectively). The HRT3 thickness measurements were in good agreement with the manual StratusOCT measurements (P = 0.4).

CONCLUSION

In normal and DME eyes, the HRT3 measurements correlated well with the automatic StratusOCT measurements. In AMD eyes, the HRT3 measurements correlated well only with the manually corrected measurements of the retinal-subretinal pathologic changes.

摘要

目的

评估使用新型海德堡视网膜断层扫描仪（HRT3）算法进行的黄斑厚度和体积测量，并将结果与光相干断层扫描（StratusOCT）进行比较。

方法

这是一项前瞻性、对照、临床非介入性研究。使用两种方法检查了 52 只眼：16 只正常眼、12 只糖尿病性黄斑水肿（DME）眼和 24 只年龄相关性黄斑变性（AMD）眼。将 HRT3 黄斑厚度和体积与 StratusOCT 自动软件的结果进行比较。此外，使用 StratusOCT 手动卡尺技术测量视网膜表面与视网膜下病理改变基底之间的距离，并将 AMD 眼中的 HRT3 测量值进行比较。

结果

在正常眼（P = 0.89 和 P = 0.33）和 DME 眼（P = 0.86 和 P = 0.31）中，两种方法的黄斑厚度和体积测量值之间无统计学差异。然而，在 AMD 眼中，两种方法的测量值之间差异均具有统计学意义（P < 0.0001 和 P < 0.0001）。HRT3 厚度测量值与手动 StratusOCT 测量值具有良好的一致性（P = 0.4）。