巴西日托中心儿童中不敏感鼻咽部肺炎链球菌分离株的调查。
Survey of nonsusceptible nasopharyngeal Streptococcus pneumoniae isolates in children attending day-care centers in Brazil.
机构信息
Secretariat of Health, Municipality of Goiania, Goiás State, Brazil.
出版信息
Pediatr Infect Dis J. 2010 Jan;29(1):77-9. doi: 10.1097/INF.0b013e3181af7e90.
Abstract
A survey of nasopharyngeal carriage of penicillin nonsusceptible pneumococcal (PNSp) isolates was conducted among 1192 children attending 62 day care centers in Brazil, where pneumococcal vaccination has not been routinely introduced. Nasopharyngeal pneumococcal carriage was detected in 686 (57.6%) infants, and 178 (25.9%) of them carried PNSp isolates. Being less than 24 months of age, hospitalization in the previous 3 months, and recurrent acute otitis media were independently associated with PNSp. Serotypes 14, 23F, 19A, 6A, 6B and 19F were the most common serotype isolated accounting for 80% of the PNSp. A high proportion (35/332) of non-(sero)typeable isolates was detected, 62.9% of them PNSp. Serotypes coverage projected for the pneumococcal conjugate vaccine (PCV) 13-valent vaccine (72%) was significantly higher compared with PCV7 (58.4%) and PCV 10-valent vaccine (59.3%).
摘要
在巴西的 62 家日托中心，对 1192 名儿童进行了鼻咽青霉素不敏感肺炎球菌（PNSp）分离株携带情况的调查，这些中心尚未常规接种肺炎球菌疫苗。在 686 名（57.6%）婴儿中检测到鼻咽肺炎球菌携带，其中 178 名（25.9%）携带 PNSp 分离株。年龄小于 24 个月、过去 3 个月住院治疗和反复急性中耳炎与 PNSp 独立相关。血清型 14、23F、19A、6A、6B 和 19F 是最常见的分离血清型，占 PNSp 的 80%。检测到高比例（35/332）的非（血清）型分离株，其中 62.9%为 PNSp。与 PCV7（58.4%）和 PCV10 价疫苗（59.3%）相比，13 价肺炎球菌结合疫苗（PCV）的血清型覆盖率（72%）显著更高。
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