D'Addario Adriana, Galuppo Juan, Navari Carlos, Schultz Marcelo, Cuello Nélida, Troncoso Juan C, Riudavets Miguel Angel
Forensic Office, Forensic Medical Corps, Buenos Aires, Argentina.
Am J Forensic Med Pathol. 2010 Mar;31(1):83-4. doi: 10.1097/PAF.0b013e3181c21c10.
We describe a case of accidental intrathecal administration of vincristine in a 33-year-old man with clinical diagnosis of acute lymphocytic leukemia. The patient died 20 days after receiving the drug. Clinically, the patient developed acute ascending paralysis with motor and sensory dysfunctions, and respiratory failure. Neuropathological investigation revealed lesions in spinal cord, roots, and cerebellum characterized by rarefaction of the neuropil, axonal, and myelin degeneration, accompanied by macrophagic infiltration.
