Schulmeister Lisa
Clin J Oncol Nurs. 2006 Apr;10(2):271-3. doi: 10.1188/06.CJON.271-273.
Although vincristine sulfate is indicated for IV use only, it has been inadvertently administered intrathecally. Accidental vincristine administration via the spinal route (intrathecally via a lumbar puncture or intraventricularly via an Ommaya reservoir) causes rapid sensory and motor dysfunction, usually followed by encephalopathy, coma, and death (Schulmeister, 2004). Autopsy findings include grossly edematous and congested brain and spinal cord tissue, with axonal degeneration and myelin loss of the spinal nerves (Kwack et al., 1999; Williams et al., 1983).
尽管硫酸长春新碱仅适用于静脉注射，但仍有意外鞘内给药的情况发生。通过脊髓途径意外注射长春新碱（经腰椎穿刺鞘内注射或通过奥马亚贮器脑室内注射）会迅速导致感觉和运动功能障碍，通常随后会出现脑病、昏迷和死亡（舒尔迈斯特，2004年）。尸检结果包括脑和脊髓组织明显水肿和充血，伴有脊神经轴突变性和髓鞘脱失（夸克等人，1999年；威廉姆斯等人，1983年）。
