抗血小板治疗：替格瑞洛在急性冠脉综合征中的应用——PLATO研究给我们带来了什么启示？ - Suppr

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超能文献

Antiplatelet therapy: Ticagrelor in ACS-what does PLATO teach us?

作者信息

Bhatt Deepak L

出版信息

Nat Rev Cardiol. 2009 Dec;6(12):737-8. doi: 10.1038/nrcardio.2009.192.

DOI:10.1038/nrcardio.2009.192

PMID:19935680

Abstract

摘要

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Antiplatelet therapy: Ticagrelor in ACS-what does PLATO teach us?抗血小板治疗：替格瑞洛在急性冠脉综合征中的应用——PLATO研究给我们带来了什么启示？

Nat Rev Cardiol. 2009 Dec;6(12):737-8. doi: 10.1038/nrcardio.2009.192.

Effect size of ticagrelor over clopidogrel in the Platelet Inhibition and Patient Outcomes (PLATO) trial: from statistics to clinical judgment.替格瑞洛与氯吡格雷相比在血小板抑制和患者预后（PLATO）试验中的效应大小：从统计学到临床判断

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Cardiovascular events in acute coronary syndrome patients with peripheral arterial disease treated with ticagrelor compared with clopidogrel: Data from the PLATO Trial.替格瑞洛与氯吡格雷治疗伴外周动脉疾病的急性冠脉综合征患者的心血管事件：来自 PLATO 试验的数据。

Eur J Prev Cardiol. 2015 Jun;22(6):734-42. doi: 10.1177/2047487314533215. Epub 2014 May 15.

Ticagrelor vs. clopidogrel in Japanese, Korean and Taiwanese patients with acute coronary syndrome -- randomized, double-blind, phase III PHILO study.替格瑞洛与氯吡格雷用于日本、韩国及台湾地区急性冠脉综合征患者的比较——随机、双盲、III期PHILO研究

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Ticagrelor versus clopidogrel in elderly patients with acute coronary syndromes: a substudy from the prospective randomized PLATelet inhibition and patient Outcomes (PLATO) trial.替格瑞洛与氯吡格雷用于老年急性冠脉综合征患者的疗效比较：前瞻性随机血小板抑制与患者预后（PLATelet inhibition and patient Outcomes，PLATO）试验的一项子研究

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Ticagrelor versus clopidogrel in Asian patients with acute coronary syndrome: A retrospective analysis from the Platelet Inhibition and Patient Outcomes (PLATO) Trial.替格瑞洛与氯吡格雷用于亚洲急性冠状动脉综合征患者的疗效比较：来自血小板抑制与患者预后（PLATO）试验的回顾性分析

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Cost-effectiveness of 12-month treatment with ticagrelor compared with clopidogrel in the management of acute coronary syndromes.替格瑞洛与氯吡格雷治疗急性冠脉综合征 12 个月的成本效果比较。

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Serum uric acid levels during dual antiplatelet therapy with ticagrelor or clopidogrel: Results from a single-centre study.替格瑞洛或氯吡格雷双联抗血小板治疗期间的血清尿酸水平：一项单中心研究的结果

Nutr Metab Cardiovasc Dis. 2016 Jul;26(7):567-574. doi: 10.1016/j.numecd.2016.03.001. Epub 2016 Mar 15.

引用本文的文献

Expert consensus document: World Heart Federation expert consensus statement on antiplatelet therapy in East Asian patients with ACS or undergoing PCI.专家共识文件：世界心脏联合会专家共识声明：抗血小板治疗在东亚 ACS 或 PCI 患者中的应用。

Nat Rev Cardiol. 2014 Oct;11(10):597-606. doi: 10.1038/nrcardio.2014.104. Epub 2014 Aug 26.

Antiplatelet therapy in the management of cardiovascular disease in patients with CKD: what is the evidence?在慢性肾脏病患者的心血管疾病管理中应用抗血小板治疗：有何证据？

Clin J Am Soc Nephrol. 2013 Apr;8(4):665-74. doi: 10.2215/CJN.06790712. Epub 2012 Sep 27.

Antiplatelet therapy in acute coronary syndromes: focus on ticagrelor.急性冠状动脉综合征中的抗血小板治疗：聚焦替格瑞洛

J Blood Med. 2010;1:197-219. doi: 10.2147/JBM.S9650. Epub 2010 Sep 1.

The evolution of antiplatelet therapy in cardiovascular disease.抗血小板治疗在心血管疾病中的演变。

Nat Rev Cardiol. 2011 Jul 12;8(10):547-59. doi: 10.1038/nrcardio.2011.96.

Overcoming 'resistance' to antiplatelet therapy: targeting the issue of nonadherence.克服抗血小板治疗的“抵抗”：针对不依从问题。

Nat Rev Cardiol. 2010 Aug;7(8):461-7. doi: 10.1038/nrcardio.2010.71. Epub 2010 Jun 1.

本文引用的文献

Ticagrelor versus clopidogrel in patients with acute coronary syndromes.替格瑞洛与氯吡格雷用于急性冠脉综合征患者的比较

N Engl J Med. 2009 Sep 10;361(11):1045-57. doi: 10.1056/NEJMoa0904327. Epub 2009 Aug 30.

Tailoring antiplatelet therapy based on pharmacogenomics: how well do the data fit?基于药物基因组学定制抗血小板治疗：数据的契合度如何？

JAMA. 2009 Aug 26;302(8):896-7. doi: 10.1001/jama.2009.1249.

Prasugrel in clinical practice.普拉格雷在临床实践中的应用。

N Engl J Med. 2009 Sep 3;361(10):940-2. doi: 10.1056/NEJMp0806848. Epub 2009 Jul 15.

Appropriate use of drug-eluting stents: balancing the reduction in restenosis with the concern of late thrombosis.药物洗脱支架的合理使用：在降低再狭窄与关注晚期血栓形成之间取得平衡。

Lancet. 2008 Jun 21;371(9630):2134-43. doi: 10.1016/S0140-6736(08)60922-8.

Is prasugrel superior to clopidogrel for patients with acute coronary syndromes undergoing PCI?对于接受经皮冠状动脉介入治疗（PCI）的急性冠状动脉综合征患者，普拉格雷是否优于氯吡格雷？

Nat Clin Pract Cardiovasc Med. 2008 May;5(5):252-3. doi: 10.1038/ncpcardio1164. Epub 2008 Mar 25.

Prasugrel versus clopidogrel in patients with acute coronary syndromes.普拉格雷与氯吡格雷用于急性冠状动脉综合征患者的比较。

N Engl J Med. 2007 Nov 15;357(20):2001-15. doi: 10.1056/NEJMoa0706482. Epub 2007 Nov 4.

Scientific and therapeutic advances in antiplatelet therapy.抗血小板治疗的科学与治疗进展。

Nat Rev Drug Discov. 2003 Jan;2(1):15-28. doi: 10.1038/nrd985.

Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial.经皮冠状动脉介入治疗后早期持续双重口服抗血小板治疗：一项随机对照试验。

JAMA. 2002 Nov 20;288(19):2411-20. doi: 10.1001/jama.288.19.2411.

Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation.氯吡格雷联合阿司匹林对非ST段抬高急性冠脉综合征患者的影响。

N Engl J Med. 2001 Aug 16;345(7):494-502. doi: 10.1056/NEJMoa010746.

A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee.氯吡格雷与阿司匹林对缺血性事件高危患者的随机、双盲试验（CAPRIE）。CAPRIE指导委员会。

Lancet. 1996 Nov 16;348(9038):1329-39. doi: 10.1016/s0140-6736(96)09457-3.

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