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Evidence for a common pathway linking neurodegenerative diseases.

作者信息

Shulman Joshua M, De Jager Philip L

出版信息

Nat Genet. 2009 Dec;41(12):1261-2. doi: 10.1038/ng1209-1261.

DOI:10.1038/ng1209-1261
PMID:19935760
Abstract
摘要

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Evidence for a common pathway linking neurodegenerative diseases.连接神经退行性疾病的共同途径的证据。
Nat Genet. 2009 Dec;41(12):1261-2. doi: 10.1038/ng1209-1261.
2
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Structural neurology: are seeds at the root of neuronal degeneration?结构神经学：神经元变性的根源是种子吗？
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Modelling neurodegenerative diseases in Drosophila: a fruitful approach?在果蝇中模拟神经退行性疾病：一种富有成效的方法？
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The cell and molecular biology of glaucoma: common neurodegenerative pathways and relevance to glaucoma.青光眼的细胞与分子生物学：常见神经退行性通路及其与青光眼的相关性
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7
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Mitochondrial DNA damage and repair in neurodegenerative disorders.神经退行性疾病中的线粒体DNA损伤与修复
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本文引用的文献

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Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.全基因组关联研究确定了四个位点的常见变异为帕金森病的遗传风险因素。
Nat Genet. 2009 Dec;41(12):1303-7. doi: 10.1038/ng.485. Epub 2009 Nov 15.
2
Genome-wide association study reveals genetic risk underlying Parkinson's disease.全基因组关联研究揭示帕金森病的遗传风险。
Nat Genet. 2009 Dec;41(12):1308-12. doi: 10.1038/ng.487. Epub 2009 Nov 15.
3
Genomewide association study for susceptibility genes contributing to familial Parkinson disease.
神经元干扰素-β-干扰素α受体缺乏导致路易体和帕金森病样痴呆。
Cell. 2015 Oct 8;163(2):324-39. doi: 10.1016/j.cell.2015.08.069.
4
Unleashing the therapeutic potential of human kallikrein-related serine proteases.释放人激肽释放酶相关丝氨酸蛋白酶的治疗潜力。
Nat Rev Drug Discov. 2015 Mar;14(3):183-202. doi: 10.1038/nrd4534. Epub 2015 Feb 20.
5
Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus.阿尔茨海默病与帕金森病在微管相关蛋白tau（MAPT）基因座上的遗传重叠。
Mol Psychiatry. 2015 Dec;20(12):1588-95. doi: 10.1038/mp.2015.6. Epub 2015 Feb 17.
6
A genetic screen identifies Tor as an interactor of VAPB in a Drosophila model of amyotrophic lateral sclerosis.一项遗传筛选鉴定出 Tor 是果蝇肌萎缩性侧索硬化症模型中 VAPB 的相互作用蛋白。
Biol Open. 2014 Oct 31;3(11):1127-38. doi: 10.1242/bio.201410066.
7
Patterns of chronic venous insufficiency in the dural sinuses and extracranial draining veins and their relationship with white matter hyperintensities for patients with Parkinson's disease.帕金森病患者硬脑膜窦和颅外引流静脉的慢性静脉功能不全模式及其与白质高信号的关系。
J Vasc Surg. 2015 Jun;61(6):1511-20.e1. doi: 10.1016/j.jvs.2014.02.021. Epub 2014 Mar 19.
8
Neurite outgrowth stimulatory effects of culinary-medicinal mushrooms and their toxicity assessment using differentiating Neuro-2a and embryonic fibroblast BALB/3T3.食用药用蘑菇的神经突生长刺激作用及其对分化的 Neuro-2a 和胚胎成纤维细胞 BALB/3T3 的毒性评估。
BMC Complement Altern Med. 2013 Oct 11;13:261. doi: 10.1186/1472-6882-13-261.
9
Analysis of genome-wide association studies of Alzheimer disease and of Parkinson disease to determine if these 2 diseases share a common genetic risk.对阿尔茨海默病和帕金森病的全基因组关联研究进行分析，以确定这两种疾病是否具有共同的遗传风险。
JAMA Neurol. 2013 Oct;70(10):1268-76. doi: 10.1001/jamaneurol.2013.448.
10
Pleurotus giganteus (Berk.) Karunarathna & K.D. Hyde: Nutritional value and in vitro neurite outgrowth activity in rat pheochromocytoma cells.巨大革耳（Berk.）Karunarathna & K.D. Hyde：营养成分及对大鼠嗜铬细胞瘤细胞的体外神经突生长活性。
BMC Complement Altern Med. 2012 Jul 19;12:102. doi: 10.1186/1472-6882-12-102.
家族性帕金森病易感性基因的全基因组关联研究。
Hum Genet. 2009 Jan;124(6):593-605. doi: 10.1007/s00439-008-0582-9. Epub 2008 Nov 6.
4
Tau-mediated neurodegeneration in Alzheimer's disease and related disorders.阿尔茨海默病及相关疾病中tau蛋白介导的神经退行性变。
Nat Rev Neurosci. 2007 Sep;8(9):663-72. doi: 10.1038/nrn2194.
5
Mixed brain pathologies account for most dementia cases in community-dwelling older persons.混合性脑病变是社区居住老年人中大多数痴呆病例的病因。
Neurology. 2007 Dec 11;69(24):2197-204. doi: 10.1212/01.wnl.0000271090.28148.24. Epub 2007 Jun 13.
6
Parkinsonism, Lrrk2 G2019S, and tau neuropathology.帕金森综合征、亮氨酸重复激酶2基因G2019S突变与tau蛋白神经病理学
Neurology. 2006 Oct 24;67(8):1506-8. doi: 10.1212/01.wnl.0000240220.33950.0c.
7
Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data.帕金森病与神经功能正常对照的全基因组基因分型：第一阶段分析及数据公开发布
Lancet Neurol. 2006 Nov;5(11):911-6. doi: 10.1016/S1474-4422(06)70578-6.
8
Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease.α-突触核蛋白基因启动子变异性与帕金森病的协同分析
JAMA. 2006 Aug 9;296(6):661-70. doi: 10.1001/jama.296.6.661.
9
Genetics of Parkinson disease: paradigm shifts and future prospects.帕金森病的遗传学：范式转变与未来展望。
Nat Rev Genet. 2006 Apr;7(4):306-18. doi: 10.1038/nrg1831.
10
High-resolution whole-genome association study of Parkinson disease.帕金森病的高分辨率全基因组关联研究。
Am J Hum Genet. 2005 Nov;77(5):685-93. doi: 10.1086/496902. Epub 2005 Sep 9.