Bahwere Paluku, Sadler Kate, Collins Steve
Valid International, Oxford, United Kingdom.
Patient Prefer Adherence. 2009 Nov 3;3:67-75. doi: 10.2147/ppa.s4636.
A prospective descriptive study to assess acceptability and effectiveness of a locally made ready-to-use therapeutic food (RUTF) in HIV-infected chronically sick adults (CSA) with mid-upper-arm circumference (MUAC) <210 mm or pitting edema.
Sixty-three wasted AIDS adults were prescribed 500 g representing ~2600 kcal/day of locally made RUTF for three months and routine cotrimoxazole. Weight, height, MUAC, Karnofsky score and morbidity were measured at admission and at monthly intervals. The amount of RUTF intake and acceptability were assessed monthly.
Ninety-five percent (60/63) of the CSA that were invited to join the study agreed to participate. Mean daily intake in these 60 patients was 300 g/person/day (~1590 Kcal and 40 g of protein). Overall, 73.3% (44/60) gained weight, BMI, and MUAC. The median weight, MUAC and BMI gains after three months were 3.0 kg, 25.4 mm, and 1.1 kg/m(2), respectively. The intervention improved the physical activity performance of participants and 78.3% (47/60) regained sufficient strength to walk to the nearest health facility. Mortality at three months was 18.3% (11/60).
Locally made RUTF was acceptable to patients and was associated with a rapid weight gain and physical activity performance. The intervention is likely to be more cost effective than nutritional support using usual food-aid commodities.
一项前瞻性描述性研究，旨在评估一种本地生产的即用型治疗性食品（RUTF）对中上臂围（MUAC）<210 mm或有凹陷性水肿的HIV感染慢性病成人（CSA）的可接受性和有效性。
为63名消瘦的艾滋病成人患者开具了500克本地生产的RUTF（约2600千卡/天），为期三个月，并给予常规复方新诺明。在入院时及每月测量体重、身高、MUAC、卡诺夫斯基评分和发病率。每月评估RUTF的摄入量和可接受性。
受邀参加该研究的CSA中有95%（60/63）同意参与。这60名患者的平均每日摄入量为300克/人/天（约1590千卡和40克蛋白质）。总体而言，73.3%（44/60）的患者体重、BMI和MUAC增加。三个月后的体重、MUAC和BMI增加中位数分别为3.0千克、25.4毫米和1.1千克/米²。该干预改善了参与者的身体活动表现，78.3%（47/60）的人恢复了足够的体力走到最近的医疗机构。三个月时的死亡率为18.3%（11/60）。
患者可接受本地生产的RUTF，且其与体重快速增加和身体活动表现相关。该干预可能比使用常规食品援助商品进行营养支持更具成本效益。
