Lanciano R M, Martz K, Coia L R, Hanks G E
Department of Radiation Oncology, Fox Chase Cancer Center-University of Pennsylvania, Philadelphia 19111.
Int J Radiat Oncol Biol Phys. 1991 Jan;20(1):95-100. doi: 10.1016/0360-3016(91)90143-r.
This report reviews 271 patients with Stage III-B squamous cell cancer of the uterine cervix from three national surveys conducted by the Patterns of Care Study. A progressive increase in local control and survival is seen among the three surveys which parallels a progressive increase in paracentral (point A) dose and use of intracavitary treatment. Multivariate analysis reveals extent of pelvic disease (unilateral sidewall vs. bilateral sidewall vs. lower 1/3 vagina) and use of intracavitary treatment to be the only significant tumor and treatment factors associated with local control and survival. With aggressive radiotherapy, local control rates exceeding 65% and survival of 50% at 4 years can be anticipated at the expense of a small increase in complications.
本报告回顾了由治疗模式研究进行的三项全国性调查中的271例III - B期子宫颈鳞状细胞癌患者。在三项调查中，局部控制率和生存率逐步提高，这与宫旁（A点）剂量的逐步增加以及腔内治疗的使用情况相平行。多变量分析显示，盆腔疾病范围（单侧侧壁 vs. 双侧侧壁 vs. 阴道下1/3）和腔内治疗的使用是与局部控制和生存相关的仅有的重要肿瘤和治疗因素。通过积极的放射治疗，可以预期局部控制率超过65%，4年生存率为50%，但并发症会略有增加。
