Department of ENT, University Hospital, Nancy, France.
Rhinology. 2009 Dec;47(4):396-9. doi: 10.4193/Rhin08.220.
Despite the close location of polyps with the Eustachian tube, association between nasal polyposis (NP) and otitis media with effusion (OME) has not been described in the literature. Our retrospective case-control study aimed at assessing the relative risk to develop OME when NP is associated to factors such as asthma, aspirin intolerance (AI), atopy, eosinophil infiltration of polyp tissue, and history of surgical treatment (HST). We compared the charts of 25 NP patients presenting symptomatic OME with 50 NP patients without OME. All the charts contained validated data about OME, asthma, AI, atopy, eosinophil count in polyp tissue, and HST. Our study showed that the risk to develop OME in NP patients is five times higher in patients presenting aspirin triad (NP + asthma + AI) (OR = 5.6, p = 0.009) and three times higher in HST patients (OR = 3.5, p = 0.03), than in isolated NP patients. A linear trend exists between the different degrees of respiratory disease and the risk of OME (p = 0.01). Our data suggest that the development of OME could be considered as another marker of severity of the inflammatory disease leading to NP, asthma and AI. Better characterisation of NP patients with OME could allow is to define more accurately the nature, type and severity of the underlying inflammatory process.
尽管息肉与咽鼓管位置接近，但文献中并未描述鼻息肉（NP）与分泌性中耳炎（OME）之间的关联。我们的回顾性病例对照研究旨在评估当 NP 与哮喘、阿司匹林不耐受（AI）、过敏、息肉组织中嗜酸性粒细胞浸润和手术治疗史（HST）等因素相关时，发生 OME 的相对风险。我们比较了 25 例有症状 OME 的 NP 患者和 50 例无 OME 的 NP 患者的图表。所有图表均包含关于 OME、哮喘、AI、过敏、息肉组织中嗜酸性粒细胞计数和 HST 的经过验证的数据。我们的研究表明，在同时患有阿司匹林三联症（NP+哮喘+AI）的 NP 患者中，发生 OME 的风险是单纯 NP 患者的 5.6 倍（OR=5.6，p=0.009），在接受 HST 的患者中，发生 OME 的风险是单纯 NP 患者的 3.5 倍（OR=3.5，p=0.03）。不同程度的呼吸道疾病与 OME 的风险之间存在线性趋势（p=0.01）。我们的数据表明，OME 的发展可以被视为导致 NP、哮喘和 AI 的炎症性疾病严重程度的另一个标志物。对患有 OME 的 NP 患者进行更好的特征描述，可以更准确地定义潜在炎症过程的性质、类型和严重程度。
