Departments of Neurosurgery, King's College Hospital, Denmark Hill, London SE5 9RS, UK.
Acta Neurochir (Wien). 2010 Jun;152(6):1075-7. doi: 10.1007/s00701-009-0555-3. Epub 2009 Nov 20.
Low-grade primary T-cell lymphoma of the central nervous system is extremely rare. We present a case developing in a previously fit young woman presenting with symptoms of raised intracranial pressure and found on CT to have a cerebellar mass. Biopsy of this lesion revealed features of non-Hodgkin's lymphoma with histochemical analysis confirming T-cell phenotype and a Ki67 proliferation index of only 1%. Contrary to the prevailing view in the literature, the patient's clinical condition deteriorated following high-dose intravenous methotrexate and improved after a short course of whole-brain radiotherapy.
中枢神经系统低度原发性 T 细胞淋巴瘤极为罕见。我们报告 1 例此前健康的年轻女性病例，其表现为颅内压升高的症状，CT 检查发现小脑肿块。对该病变的活检显示非霍奇金淋巴瘤的特征，组织化学分析证实 T 细胞表型，Ki67 增殖指数仅为 1%。与文献中的主流观点相反，患者在接受大剂量静脉注射甲氨蝶呤后病情恶化，并在全脑放疗后短暂疗程后改善。
