Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Kita-15, Nishi-7, Kita-Ku, Sapporo, Hokkaido, 060-8638, Japan.
Eur J Nucl Med Mol Imaging. 2010 Jun;37(6):1213-24. doi: 10.1007/s00259-009-1311-x. Epub 2009 Nov 24.
Cardiac PET has the unique ability to assess coronary flow reserve and coronary endothelial function on the basis of response of blood flow to pharmacological stress and the cold pressor test. Quantitative analysis of coronary vasomotor function is valuable for precise assessment of function and treatment monitoring in the presence of various coronary risk factors. In addition, recent data have shown prognostic value of PET assessment of coronary vasomotor imaging in patients with suspected coronary artery disease. Thus, quantitative analysis of PET has a great potential for wide application in identifying microcirculatory dysfunction and "individualized" monitoring of the effects of primary or preventive medical intervention to optimize cardiovascular outcome.
心脏 PET 具有独特的能力，可根据血流对药物刺激和冷加压试验的反应来评估冠状动脉血流储备和冠状动脉内皮功能。定量分析冠状动脉血管舒缩功能对于在存在各种冠状动脉危险因素的情况下进行功能精确评估和治疗监测具有重要价值。此外，最近的数据表明，在疑似冠心病患者中，PET 评估冠状动脉血管舒缩成像具有预后价值。因此，PET 的定量分析具有很大的应用潜力，可用于识别微血管功能障碍，并对原发性或预防性医学干预的效果进行“个体化”监测，以优化心血管结局。
