Kunimura Toshiaki, Yoshida Tomohiko, Sugiyama Tomoko, Morohoshi Toshio
First Department of Pathology, Showa University School of Medicine, 5 Hatanodai-1, Shinagawa-ku, Tokyo 142-8666, Japan.
J Gastrointest Cancer. 2009;40(3-4):115-8. doi: 10.1007/s12029-009-9100-0.
The aim of the present study was to evaluate the standard CD44 (CD44s) expression in colorectal cancer (CRC) with invasion to the subserosal layer (T3), its relationship with clinicopathological characteristics, and its potential metastatic significance.
CD44s expression was measured on immunohistochemistry in tumors from 65 patients with primary colorectal carcinomas. CD44s expression was estimated at the deepest invaded area of the tumor in subserosal layer.
CD44s was demonstrated in 35.4% (23/65). CD44s expression showed no significant relationship with the clinicopathological characteristics such as age, gender, tumor location, tumor size, and macroscopic/microscopic classification. However, the CD44s expression showed significantly adverse relationship with lymph node metastasis (p < 0.05) and liver metastasis (p < 0.01), respectively.
The loss of CD44s expression in cancer cells in the deepest invaded area is a good marker for predicting potential metastasis to lymph nodes and liver in T3 CRC.
本研究旨在评估浸润至浆膜下层（T3）的结直肠癌（CRC）中标准CD44（CD44s）的表达情况、其与临床病理特征的关系以及潜在的转移意义。
采用免疫组织化学方法检测65例原发性结直肠癌患者肿瘤组织中CD44s的表达。在肿瘤浸润至浆膜下层的最深部位评估CD44s的表达。
CD44s阳性表达率为35.4%（23/65）。CD44s表达与年龄、性别、肿瘤位置、肿瘤大小以及大体/显微镜下分类等临床病理特征无显著相关性。然而，CD44s表达分别与淋巴结转移（p<0.05）和肝转移（p<0.01）呈显著负相关。
肿瘤最深浸润部位癌细胞中CD44s表达缺失是预测T3期结直肠癌发生淋巴结和肝转移可能性的良好指标。
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