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α-亚甲基-γ-丁内酯的复兴:新的合成方法。

The renaissance of alpha-methylene-gamma-butyrolactones: new synthetic approaches.

机构信息

Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK.

出版信息

Angew Chem Int Ed Engl. 2009;48(50):9426-51. doi: 10.1002/anie.200903108.

Abstract

The amount of research activity concerning alpha-methylene-gamma-butyrolactones and alpha-alkylidene-gamma-butyrolactones has increased dramatically in recent years. This Review summarizes the structural types, biological activities, and biosynthesis of these compounds, concentrating on publications from the past 10 years. Traditional approaches to alpha-methylene-gamma-butyrolactones and alpha-alkylidene-gamma-butyrolactones are then reviewed together with novel approaches, including those from our own research group, reported more recently.

摘要

近年来,关于α-亚甲基-γ-丁内酯和α-亚烷基-γ-丁内酯的研究活动急剧增加。本综述总结了这些化合物的结构类型、生物活性和生物合成,重点关注了过去 10 年的出版物。然后,本文综述了传统的α-亚甲基-γ-丁内酯和α-亚烷基-γ-丁内酯方法,以及包括我们自己的研究小组在内的较新报道的新型方法。

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