多米诺反应实现了锌介导的由异吲哚酮衍生物和2-(溴甲基)丙烯酸酯直接合成螺稠合的2-氧化吲哚-α-亚甲基-γ-丁内酯/内酰胺。
Domino Reactions Enable Zn-Mediated Direct Synthesis of Spiro-Fused 2-Oxindole-α-Methylene-γ-Butyrolactones/Lactams from Isatin Derivatives and 2-(Bromomethyl)acrylates.
作者信息
Mukthapuram Prathap Reddy, Natarajan Amarnath
机构信息
Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 698198, USA.
出版信息
Molecules. 2024 Jul 30;29(15):3612. doi: 10.3390/molecules29153612.
Isatin-derived spirocyclic cores are found in several biologically active molecules. Here, we report nucleophilic domino reactions for the synthesis of α-methylene-γ-butyrolactone/lactam containing spirocyclic oxindoles. The Zn-mediated one-step reaction accommodates a range of substrates and can be used to rapidly generate focused libraries of highly substituted spirocyclic compound.
异吲哚酮衍生的螺环核心存在于多种生物活性分子中。在此，我们报道了用于合成含α-亚甲基-γ-丁内酯/内酰胺的螺环氧化吲哚的亲核多米诺反应。锌介导的一步反应适用于一系列底物，可用于快速生成高度取代的螺环化合物的聚焦文库。
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