Luo Yongwei, Shi Chang, Liao Mingyang
National Beijing Center for Drug Safety Evaluation and Research, Beijing Institute of Pharmacology and Toxicology, Academy of Military Medical Science, Beijing 100850, China.
Zhongguo Zhong Yao Za Zhi. 2009 Aug;34(16):2024-6.
Triptolide, an epoxidated diterpene lactone compound separated from a traditional Chinese medicine, Tripterygium wilfordiiHook. f (TWHF), is responsible for the anti-tumor activity of TWHF with broad spectrum and high performance. The antitumor mechanism of triptolide locates in many fields, such as inducing apoptosis of tumor cell, interfering in the cell cycle, and suppressing angiogeneis. The advance in the anti-tumor mechanism of triptolide is described in the following review.
雷公藤甲素是从传统中药雷公藤中分离出的一种环氧化二萜内酯化合物，具有广谱、高效的抗肿瘤活性。雷公藤甲素的抗肿瘤机制涉及多个领域，如诱导肿瘤细胞凋亡、干扰细胞周期和抑制血管生成。以下综述介绍了雷公藤甲素抗肿瘤机制的研究进展。
