Wild T F, Malvoisin E, Buckland R
Immunovirologie Moléculaire et Cellulaire, UMR 30/CNRS, Faculté de Médicine Alexis Carrel, Lyon, France.
J Gen Virol. 1991 Feb;72 ( Pt 2):439-42. doi: 10.1099/0022-1317-72-2-439.
Vaccinia-measles recombinant viruses were used to examine the contribution of the individual measles virus glycoproteins in fusion. Although vaccinia virus recombinants expressing either the haemagglutinin or fusion proteins did not induce fusion in the cell lines examined, a double recombinant expressing both measles virus glycoproteins gave extensive syncytia in cells of human and simian origin. No fusion was observed in mouse, hamster or chicken cells. The fusion induced by the double recombinant could be specifically inhibited with either anti-fusion or anti-haemagglutinin monoclonal antibodies.
痘苗-麻疹重组病毒被用于研究单个麻疹病毒糖蛋白在融合过程中的作用。尽管表达血凝素或融合蛋白的痘苗病毒重组体在检测的细胞系中未诱导融合，但同时表达两种麻疹病毒糖蛋白的双重组体在人和猴源细胞中产生了广泛的多核巨细胞。在小鼠、仓鼠或鸡细胞中未观察到融合现象。双重组体诱导的融合可被抗融合或抗血凝素单克隆抗体特异性抑制。
