Department of Applied Chemistry, Institute of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan.
Org Lett. 2010 Jan 1;12(1):148-51. doi: 10.1021/ol9025556.
The first three-component reaction of norbornene with two alkynes leading to 1,5-enyne via C-H bond activation of terminal silylacetylene was achieved using a Ni(cod)(2)/phosphine catalyst. This reaction is applicable for various internal alkynes and norbornene derivatives with high regio- and stereoselectivities.
通过使用 Ni(cod)(2)/膦催化剂，实现了降冰片烯与两个炔烃的前三个组分反应，通过末端硅基乙炔的 C-H 键活化生成 1,5-烯炔。该反应适用于各种内部炔烃和降冰片烯衍生物，具有高区域和立体选择性。
