Muscular & Neurodegenerative Diseases Unit, Institute G. Gaslini, Genova, Italy.
Expert Opin Investig Drugs. 2009 Dec;18(12):1875-84. doi: 10.1517/13543780903369341.
In the last fifteen years, new antiepileptic medications have been offered for the treatment of patients with epilepsy. Nevertheless, despite optimal medical treatment, up to 30% of patients still experience recurrent seizures and the challenge for new, more efficacious and better-tolerated drugs continues. New antiepileptic drugs include the evolution of pre-existing drugs and new compounds identified through the investigation of additional molecular targets, such as SV2A synaptic vesicle protein, voltage-gated potassium channels, ionotropic and metabotropic glutamate receptors, and gap junctions. This paper reviews the available information on various classes of molecules that are in the pipeline as well as on the innovative approaches to the treatment of epilepsy.
在过去的十五年中，已经有新的抗癫痫药物被用于治疗癫痫患者。然而，尽管进行了最佳的药物治疗，仍有高达 30%的患者仍然经历着反复发作的癫痫，因此仍然需要寻找新的、更有效和更好耐受的药物。新的抗癫痫药物包括现有药物的改进和通过研究新的分子靶点（如 SV2A 突触囊泡蛋白、电压门控钾通道、离子型和代谢型谷氨酸受体以及缝隙连接）发现的新化合物。本文综述了不同类别分子的现有信息，以及治疗癫痫的创新方法。
