Arnold D L, Emrich J F, Shoubridge E A, Villemure J G, Feindel W
McConnell Brain Imaging Center, Montreal Neurological Institute and Hospital, McGill University, Quebec, Canada.
J Neurosurg. 1991 Mar;74(3):447-53. doi: 10.3171/jns.1991.74.3.0447.
Phosphorus magnetic resonance (MR) spectroscopy allows noninvasive measurement of phosphate-containing compounds and pH within brain cells. The authors obtained localized phosphorus MR spectra from 10 normal brains, four low-grade astrocytomas, six glioblastomas, four meningiomas, and three pituitary adenomas and found differences in the spectra of each tumor type. Compared to normal brain, the spectra from low-grade astrocytomas showed a significant reduction of the phosphodiester (PDE) peak. Glioblastomas were characterized by a significant reduction of the PDE peak, elevation of the phosphomonoester (PME) peak, and a relatively alkaline intracellular pH. The spectra from meningiomas and pituitary adenomas were markedly different from the glial tumors. Meningiomas showed significant reductions in phosphocreatine, PDE, and inorganic phosphate, as well as a relatively alkaline pH. Pituitary adenomas resembled meningiomas, but had a much higher PME peak. Although the number of tumors studied was small, there appears to be a characteristic spectrum associated with these different tumor types. The present findings can be useful in the preoperative identification of these tumors and in furthering understanding of their growth and metabolism in vivo.
磷磁共振（MR）波谱分析可对脑细胞内的含磷化合物和pH值进行无创测量。作者从10个正常大脑、4个低级别星形细胞瘤、6个胶质母细胞瘤、4个脑膜瘤和3个垂体腺瘤中获取了局部磷MR波谱，发现每种肿瘤类型的波谱存在差异。与正常大脑相比，低级别星形细胞瘤的波谱显示磷酸二酯（PDE）峰显著降低。胶质母细胞瘤的特征是PDE峰显著降低、磷酸单酯（PME）峰升高以及细胞内pH值相对偏碱性。脑膜瘤和垂体腺瘤的波谱与胶质肿瘤明显不同。脑膜瘤的磷酸肌酸、PDE和无机磷酸盐显著降低，且pH值相对偏碱性。垂体腺瘤与脑膜瘤相似，但PME峰要高得多。尽管所研究的肿瘤数量较少，但似乎存在与这些不同肿瘤类型相关的特征性波谱。目前的研究结果有助于这些肿瘤的术前识别，并有助于进一步了解它们在体内的生长和代谢情况。
