Miyamachi K, Abe H, Miyasaka K
Department of Neurosurgery, Hokkaido University, School of Medicine.
No Shinkei Geka. 1990 Jun;18(6):533-7.
Eleven normal volunteers and 17 subjects with brain tumors were studied by phosphorus-31 Magnetic Resonance (MR) spectroscopy. Measurements were performed by FROGS (Fast Rotating Gradient Spectroscopy) saturating nearly skin or muscle by Volume of Interest (VOI). This measurement took about 30 minutes for each case, including the imaging procedure, shimming and the measuring of spectroscopy. In phosphorus-31 MR spectroscopy, pH of the subjects with brain tumors showed a statistically significant elevation compared with that of the volunteers. In the subjects with benign tumors, only the elevation of pH was significant compared with that in volunteers. There was no other difference. This result suggests that benign tumors have an almost normal metabolic mechanism. Malignant brain tumors showed a decrease of PCr and an increase of Pi and PME. The increase of Pi indicates the increase of energy consumption. The increase of PME is connected with the acceleration of cell proliferation, there is a difference between malignant tumors and benign tumors. Phosphorus-31 spectroscopy has the potential to investigate the metabolism in vivo.
11名正常志愿者和17名脑肿瘤患者接受了磷-31磁共振（MR）波谱检查。测量采用快速旋转梯度波谱（FROGS）技术，通过感兴趣区（VOI）使皮肤或肌肉接近饱和状态。每个病例的测量过程约需30分钟，包括成像程序、匀场和波谱测量。在磷-31 MR波谱检查中，脑肿瘤患者的pH值与志愿者相比有统计学意义的升高。在良性肿瘤患者中，仅pH值升高与志愿者相比有显著性差异，无其他差异。该结果提示良性肿瘤具有几乎正常的代谢机制。恶性脑肿瘤表现为磷酸肌酸（PCr）降低，无机磷（Pi）和磷酸单酯（PME）升高。Pi升高表明能量消耗增加。PME升高与细胞增殖加速有关，恶性肿瘤与良性肿瘤存在差异。磷-31波谱有潜力用于研究体内代谢。
