School of Paediatrics and Child Health, University of Western Australia, Princess Margaret Hospital for Children, Perth, Western Australia, Australia.
J Psychopharmacol. 2011 Jan;25(1):60-70. doi: 10.1177/0269881109348164. Epub 2009 Nov 25.
Glucose administration is associated with memory enhancement in healthy young individuals under conditions of divided attention at encoding. While the specific neurocognitive mechanisms underlying this 'glucose memory facilitation effect' are currently uncertain, it is thought that individual differences in glucoregulatory efficiency may alter an individual's sensitivity to the glucose memory facilitation effect. In the present study, we sought to investigate whether basal hypothalamic-pituitary-adrenal axis function (itself a modulator of glucoregulatory efficiency), baseline self-reported stress and trait anxiety influence the glucose memory facilitation effect. Adolescent males (age range = 14-17 years) were administered glucose and placebo prior to completing a verbal episodic memory task on two separate testing days in a counter-balanced, within-subjects design. Glucose ingestion improved verbal episodic memory performance when memory recall was tested (i) within an hour of glucose ingestion and encoding, and (ii) one week subsequent to glucose ingestion and encoding. Basal hypothalamic-pituitary-adrenal axis function did not appear to influence the glucose memory facilitation effect; however, glucose ingestion only improved memory in participants reporting relatively higher trait anxiety. These findings suggest that the glucose memory facilitation effect may be mediated by biological mechanisms associated with trait anxiety.
葡萄糖给药与注意分散条件下健康年轻个体的记忆增强有关。虽然目前尚不清楚这种“葡萄糖记忆促进效应”的具体神经认知机制，但人们认为，糖调节效率的个体差异可能会改变个体对葡萄糖记忆促进效应的敏感性。在本研究中，我们试图探讨基础下丘脑-垂体-肾上腺轴功能（本身是糖调节效率的调节剂）、基线自我报告的压力和特质焦虑是否会影响葡萄糖记忆促进效应。青少年男性（年龄范围为 14-17 岁）在两个单独的测试日中，以平衡、被试内的设计，分别在服用葡萄糖和安慰剂之前完成口头情节记忆任务。当在葡萄糖摄入和编码后一小时内（i）和一周后（ii）测试记忆回忆时，葡萄糖摄入改善了口头情节记忆表现。基础下丘脑-垂体-肾上腺轴功能似乎不会影响葡萄糖记忆促进效应；然而，葡萄糖摄入仅改善了报告相对较高特质焦虑的参与者的记忆。这些发现表明，葡萄糖记忆促进效应可能是由与特质焦虑相关的生物学机制介导的。
