Section of Hematology, Department of Clinical and Experimental Medicine, Policlinico G.B. Rossi, Piazzale L.A. Scuro, University of Verona, 37134 Verona, Italy.
Oncologist. 2009 Dec;14(12):1205-8. doi: 10.1634/theoncologist.2009-0184. Epub 2009 Nov 25.
Plasmacytoid dendritic cell leukemia (pDCL) is a rapidly evolving disease, which frequently presents with skin lesions, particularly nodules and plaques with a typical reddish-brown or brown color. Treatment of pDCL is based on multiagent chemotherapy followed by allogeneic hematopoietic stem cell transplant, but skin lesions may be refractory to therapy. Here, we report on a 61-year-old patient affected by pDCL who first presented with multiple cutaneous nodules and plaques on the trunk. Lesions showed an excellent response to radiotherapy plus hyperthermia. Although this treatment did not avoid the systemic evolution of disease, it resolved skin lesions and prevented their relapse, thus representing a therapeutic option to be used in combination with chemotherapy regimens. The case presentation is followed by a general discussion with an emphasis on the diagnosis and treatment of this rare malignancy.
浆细胞样树突状细胞瘤白血病 (pDCL) 是一种快速进展的疾病，常以皮肤损害为首发表现，特别是结节和斑块，具有典型的红棕色或棕色。pDCL 的治疗基于多药化疗，随后进行异基因造血干细胞移植，但皮肤损害可能对治疗有抗性。在此，我们报告一例 61 岁的 pDCL 患者，最初表现为躯干多发性皮肤结节和斑块。病变对放疗加高热治疗有极好的反应。尽管这种治疗并不能避免疾病的全身进展，但它解决了皮肤损害，并防止其复发，因此代表了一种与化疗方案联合使用的治疗选择。病例报告后进行了一般讨论，重点是这种罕见恶性肿瘤的诊断和治疗。
