Department of Internal Medicine, Kinki Central Hospital, Hyogo, USA.
Ann Clin Biochem. 2010 Jan;47(Pt 1):39-43. doi: 10.1258/acb.2009.009127. Epub 2009 Nov 25.
In gastrectomized subjects, oral glucose tolerance test often shows marked hyperglycaemia (oxyhyperglycaemia) after glucose loading. Because serum glycated albumin (GA) has been shown to better reflect postprandial and maximum plasma glucose levels, we investigated whether or not the clinical significance of serum GA and glycated haemoglobin (HbA(1C)) in non-diabetic gastrectomized subjects differs.
During health examinations, 62 non-diabetic subjects with a history of gastrectomy and 87 non-diabetic control subjects were selected in the present study. Body mass index (BMI) in the gastrectomy group was significantly lower than in the control group.
Fasting plasma glucose levels were significantly lower in the gastrectomized subjects than in the control subjects. Although both HbA(1C) and serum GA were significantly higher in the gastrectomized subjects, there was a significant difference in GA/HbA(1C) ratio between the gastrectomized subjects and the control subjects. BMI-adjusted serum GA, based on our previous finding of inverse influence of BMI on serum GA, was also significantly higher in the gastrectomized subjects than in the controls.
Serum GA is higher relative to HbA(1C) in gastrectomized subjects. This suggests that serum GA may be a better marker than HbA(1C) for glycaemic excursion in these subjects.
在胃切除术后患者中，口服葡萄糖耐量试验（OGTT）在葡萄糖负荷后常显示明显的高血糖（氧高血糖症）。由于血清糖化白蛋白（GA）已被证明能更好地反映餐后和最大血糖水平，我们研究了非糖尿病胃切除术后患者的血清 GA 和糖化血红蛋白（HbA1C）的临床意义是否不同。
在健康检查期间，本研究选择了 62 例有胃切除术史的非糖尿病患者和 87 例非糖尿病对照组。胃切除术组的体重指数（BMI）明显低于对照组。
胃切除术后患者的空腹血糖水平明显低于对照组。尽管胃切除术后患者的 HbA1C 和血清 GA 均明显升高，但 GA/HbA1C 比值在胃切除术后患者与对照组之间存在显著差异。根据我们之前发现的 BMI 对血清 GA 的反向影响，基于 BMI 调整的血清 GA 也明显高于对照组。
胃切除术后患者的血清 GA 相对于 HbA1C 升高。这表明血清 GA 可能是这些患者血糖波动的一个比 HbA1C 更好的标志物。
