Dozio Elena, Di Gaetano Nicola, Findeisen Peter, Corsi Romanelli Massimiliano Marco
Department of Biomedical Sciences for Health, Università degli Studi di Milano, Via L. Mangiagalli 31, 20133, Milan, Italy.
Instrumentation Laboratory-A Werfen Company, R&D Department, Viale Monza 338, 20128, Milan, Italy.
Endocrine. 2017 Mar;55(3):682-690. doi: 10.1007/s12020-016-1091-6. Epub 2016 Sep 13.
This review summarizes current knowledge about glycated albumin. We review the changes induced by glycation on the properties of albumin, the pathological implications of high glycated albumin levels, glycated albumin quantification methods, and the use of glycated albumin as a complementary biomarker for diabetes mellitus diagnosis and monitoring and for dealing with long-term complications. The advantages and limits of this biomarker in different clinical settings are also discussed.
本综述总结了目前关于糖化白蛋白的知识。我们回顾了糖化作用对白蛋白性质的影响、高糖化白蛋白水平的病理意义、糖化白蛋白的定量方法，以及糖化白蛋白作为糖尿病诊断、监测及处理长期并发症的补充生物标志物的应用。还讨论了该生物标志物在不同临床环境中的优势和局限性。
