Department of Biomedical Engineering, Rutgers University, 599 Taylor Road, Piscataway, NJ 08854, USA.
Acta Biomater. 2010 Jun;6(6):1917-24. doi: 10.1016/j.actbio.2009.11.023. Epub 2009 Nov 23.
Implantable biodegradable nerve guidance conduits (NGCs) have the potential to align and support regenerating cells, as well as prevent scar formation. In this study in vitro bioassays and in vivo material evaluations were performed using a nerve guidance conduit material made from a novel polyanhydride blend. In vitro cytotoxicity studies with both fibroblasts and primary chick neurons demonstrated that the proposed polyanhydride blend was non-cytotoxic. Subcutaneous implantation for 7days in rats resulted in an initial fibrin matrix, minimal macrophage presence and angiogenesis in the surrounding tissues. Nerve guidance conduits fabricated from the proposed polyanhydride blend material may serve as favorable biocompatible tissue engineering devices.
可植入的生物可降解神经引导导管（NGCs）具有对齐和支持再生细胞以及防止疤痕形成的潜力。在这项研究中，使用一种由新型聚酸酐共混物制成的神经引导导管材料进行了体外生物测定和体内材料评估。体外成纤维细胞和原代鸡神经元的细胞毒性研究表明，所提出的聚酸酐共混物无细胞毒性。在大鼠体内皮下植入 7 天后，形成初始纤维蛋白基质，周围组织中巨噬细胞存在和血管生成较少。由所提出的聚酸酐共混物材料制成的神经引导导管可作为良好的生物相容性组织工程装置。
