Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan.
Acta Biomater. 2010 Jun;6(6):2066-76. doi: 10.1016/j.actbio.2009.12.038. Epub 2009 Dec 28.
Surface modification is a conventional approach in biomaterials development, but most of the modification processes are intricate and time inefficient. In this study, a convenient open air plasma treatment was employed to modify the surface of poly(d,l-lactide) (PLA). Chitosan and fibroblast growth factor 1 (FGF1) were sequentially grafted with the assistance of open air plasma treatment onto the PLA nerve conduits with designed micropores and surface microgrooves. Grafting of these components was verified by electron spectroscopy for chemical analysis. The modified nerve conduits showed enhanced ability in the repair of 10-mm sciatic nerve transection defects in rats. The sequential air plasma treatment can be a convenient way to introduce biocompatible (e.g., chitosan) and bioactive components (e.g., growth factors) onto the surface of biomaterials.
表面改性是生物材料开发中的一种常规方法，但大多数改性过程复杂且效率低下。在这项研究中，采用了一种方便的常压等离子体处理方法来改性聚（DL-乳酸）（PLA）的表面。壳聚糖和成纤维细胞生长因子 1（FGF1）在常压等离子体处理的辅助下，依次接枝到具有设计微孔和表面微槽的 PLA 神经导管上。电子能谱化学分析证实了这些成分的接枝。改性后的神经导管在修复大鼠 10mm 坐骨神经横断缺损方面表现出更强的能力。顺序空气等离子体处理可以方便地将生物相容性（如壳聚糖）和生物活性成分（如生长因子）引入到生物材料的表面。
