Department of Radiology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
Complement Ther Med. 2009 Oct-Dec;17(5-6):262-8. doi: 10.1016/j.ctim.2009.09.003. Epub 2009 Nov 7.
Complex regional pain syndrome type 1 (CRPS1) can develop after severe trauma or surgery in the limbs, and presents with chronic, changes in temperature, edema and dysfunction. Seventy-five percent of CRPS1 patients are female. While neurological and inflammatory components have been proposed, the etiology remains unclear. No consensus on optimal management of CRPS1 exists. In traditional Chinese medicine, menstrual disorders are related to the state of women's constitution and therefore identify their pain patterns. A classification by constitution might improve the pain management in CRPS1 patients. It is unknown whether associations exist between menstrual-cycle-conditions and CRPS1.
To investigate whether a specified menstrual condition is associated with the risk of developing CRPS1.
A population-based case-control study of CRPS1 was conducted among Dutch women aged 18-82; i.e. 34 women with CRPS1 and 147 controls. A standard questionnaire consisting of 59 menstrual-cycle-symptom-based questions was administered. From this questionnaire, 15 CRPS1-related questions (DRQ 15) were analyzed. We used multivariate logistic regression to obtain odds ratios and 95% confidence intervals (CI) for specified menstrual disorders adjusting for age, oral contraceptives, hysterectomy and age at menarche < or = 12 and > or = 17 years.
On the basis of the DRQ 15, women with CRPS1 were 5.3 (95%CI 2.1, 12.9) times more likely to have menstrual disorders than comparable controls.
Our results suggest that selected menstrual conditions are associated with the risk of developing CRPS1.
复杂性区域疼痛综合征 1 型（CRPS1）可在四肢严重创伤或手术后发生，并表现为慢性、体温变化、水肿和功能障碍。75%的 CRPS1 患者为女性。虽然已经提出了神经和炎症成分，但病因仍不清楚。CRPS1 的最佳治疗方法尚未达成共识。在中医中，月经失调与女性体质有关，因此可以确定她们的疼痛模式。通过体质分类可能会改善 CRPS1 患者的疼痛管理。目前尚不清楚月经周期状况与 CRPS1 之间是否存在关联。
研究特定的月经状况是否与发生 CRPS1 的风险相关。
对荷兰 18-82 岁的女性进行了基于人群的 CRPS1 病例对照研究；即 34 名 CRPS1 患者和 147 名对照。采用标准问卷对月经周期症状进行了 59 项调查。从这个问卷中，分析了 15 个与 CRPS1 相关的问题（DRQ 15）。我们使用多变量逻辑回归来获得比值比和 95%置信区间（CI），以调整年龄、口服避孕药、子宫切除术和初潮年龄<或=12 岁和>或=17 岁的特定月经失调。
基于 DRQ 15，CRPS1 患者发生月经失调的可能性是可比对照组的 5.3 倍（95%CI 2.1，12.9）。
我们的结果表明，某些月经状况与发生 CRPS1 的风险相关。
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