Center for Military and Veterans' Health, The University of Queensland, Brisbane, Australia.
Am J Obstet Gynecol. 2010 Jun;202(6):534.e1-6. doi: 10.1016/j.ajog.2009.10.857. Epub 2009 Dec 22.
The aim of this study was to investigate the association between early menstrual characteristics, before symptom onset, and later diagnosis of endometriosis.
This was a case-control study of 268 Australian women with surgically confirmed moderate-to-severe endometriosis (cases) and 244 women without endometriosis (controls). Early menstrual cycle characteristics, before age at symptom onset, were analyzed.
Menarche after age 14 years was strongly and inversely associated with endometriosis (odds ratio, 0.3; 95% confidence interval, 0.1-0.6). A history of dysmenorrhea was associated with subsequent endometriosis (odds ratio, 2.6; 95% confidence interval, 1.1-6.2). Despite a suggestive trend, shorter menstrual cycle length was not associated with endometriosis. Duration of natural menstruation and heaviness of flow were not associated with subsequent risk of endometriosis; neither was the reported type of sanitary protection used nor history of sexual intercourse during menstruation.
There is a decreased risk of endometriosis with late age at menarche and an increased risk in women who report an early history of dysmenorrhea.
本研究旨在探讨症状出现前早期月经特征与子宫内膜异位症后期诊断之间的关系。
这是一项对 268 名澳大利亚女性（病例组）和 244 名无子宫内膜异位症女性（对照组）的病例对照研究。分析了症状出现前早期月经周期特征。
14 岁以后初潮与子宫内膜异位症呈强烈负相关（比值比，0.3；95%置信区间，0.1-0.6）。痛经史与随后的子宫内膜异位症相关（比值比，2.6；95%置信区间，1.1-6.2）。尽管存在提示性趋势，但较短的月经周期长度与子宫内膜异位症无关。自然月经持续时间和出血量与随后发生子宫内膜异位症的风险无关；所报告的卫生用品类型以及月经期间是否有性行为史也无关。
初潮年龄较晚与子宫内膜异位症风险降低有关，而痛经史较早的女性风险增加。
