Laboratory of Neurofisiopatologia Clinica, IRCCS Fondazione Santa Lucia, Via Ardeatina 306, Rome, Italy.
Anat Rec (Hoboken). 2009 Dec;292(12):2023-31. doi: 10.1002/ar.20965.
Synchronous brain activity in motor cortex in perception or in complex cognitive processing has been the subject of several studies. The advanced analysis of cerebral electro-physiological activity during the course of planning (PRE) or execution of movement (EXE) in a high temporal resolution could reveal interesting information about the brain functional organization in patients following stroke damage. High-power (128 channels) electroencephalography registration was carried out on 8 healthy subjects and on a patient with stroke with capsular lacuna in the right hemisphere. For activation of motor cortex, the finger tapping paradigm was used. In this preliminary study, we tested a theoretical graph approach to characterize the task-related spectral coherence. All of the obtained brain functional networks were analyzed by the connectivity degree, the degree distribution, and efficiency parameters in the Theta, Alpha, Beta, and Gamma bands during the PRE and EXE intervals. All the brain networks were found to hold a regular and ordered topology. However, significant differences (P < 0.01) emerged between the patient with stroke and the control subjects, independently of the neural processes related to the PRE or EXE periods. In the Beta (13-29 Hz) and Gamma (30-40 Hz) bands, the significant (P < 0.01) decrease in global- and local-efficiency in the patient's networks, reflected a lower capacity to integrate communication between distant brain regions and a lower tendency to be modular. This weak organization is principally due to the significant (P < 0.01 Bonferroni corrected) increase in disconnected nodes together with the significant increase in the links in some other crucial vertices.
大脑运动皮层在感知或复杂认知加工过程中的同步活动一直是多项研究的主题。在规划(PRE)或执行运动(EXE)过程中,对脑电生理活动进行高级分析,以高时间分辨率,可以揭示有关脑功能组织的有趣信息,这在脑损伤后的患者中尤为重要。对 8 名健康受试者和一名右半球壳核间隙卒中患者进行了 128 通道高功率脑电图记录。为了激活运动皮层,我们使用了手指敲击范式。在这项初步研究中,我们测试了一种理论图方法来描述与任务相关的光谱相干性。在 PRE 和 EXE 间隔期间,使用连接度、度分布和效率参数对所有获得的脑功能网络进行了分析,涉及到Theta、Alpha、Beta 和 Gamma 频带。所有的脑网络都呈现出规则有序的拓扑结构。然而,无论是与 PRE 还是 EXE 期相关的神经过程,在卒中患者和对照组之间都出现了显著的差异(P < 0.01)。在 Beta(13-29 Hz)和 Gamma(30-40 Hz)频段,患者网络的全局和局部效率显著(P < 0.01)降低,反映了整合远距离脑区之间通讯的能力降低,以及模块化的趋势降低。这种较弱的组织主要是由于不相连节点的显著(P < 0.01 经 Bonferroni 校正)增加,以及在一些其他关键顶点中连接的显著增加所致。