Department of Oral Medicine, Faculty of Medicine and Odontology, University of Murcia, Murcia, Spain.
J Oral Pathol Med. 2010 Mar;39(3):201-5. doi: 10.1111/j.1600-0714.2009.00830.x. Epub 2009 Nov 20.
The search for new drugs capable of controlling the symptoms and signs of oral lichen planus (OLP) with minimal side-effects remains an important challenge.
A literature review is made to evaluate the effectiveness and safety of topical tacrolimus and pimecrolimus in the treatment of OLP.
A review was made of the studies published between 1999 and 2008 in relation to the topical application of tacrolimus and pimecrolimus in OLP.
The data obtained point to the need for larger randomized, placebo-controlled studies with carefully selected and standardized endpoints, to allow adequate comparison between treatments. The adverse effects were fundamentally of a local nature, and in particular included burning sensation in the application zone. All the studies consulted found the treatment to be effective over short periods of time, with lesion recurrences after suppression of the drug. The long-term safety remains to be established.
There is need for larger placebo-controlled, randomized studies with carefully selected and standardized outcome measures.
寻找具有最小副作用、能够控制口腔扁平苔藓（OLP）症状和体征的新药仍然是一个重要的挑战。
对局部应用他克莫司和吡美莫司治疗 OLP 的疗效和安全性进行文献评价。
对 1999 年至 2008 年间发表的关于局部应用他克莫司和吡美莫司治疗 OLP 的研究进行了综述。
获得的数据表明，需要进行更大规模的、随机的、安慰剂对照的研究，并采用精心选择和标准化的终点，以便在治疗之间进行充分的比较。不良反应主要为局部性质，特别是在应用区域有烧灼感。所有咨询的研究都发现，该治疗在短时间内有效，但在药物抑制后病变复发。长期安全性仍有待确定。
需要进行更大规模的、安慰剂对照的、随机的研究，并采用精心选择和标准化的结果测量。
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