National Centre for Immunisation Research and Surveillance Sydney, NSW, Australia.
Vaccine. 2010 Jan 22;28(4):901-6. doi: 10.1016/j.vaccine.2009.10.081. Epub 2009 Nov 25.
Limited information exists regarding optimal methods for the recruitment and retention of older people in clinical trials. The aim of this review is to identify common barriers to the recruitment of older people in clinical trials and to propose solutions to overcome these barriers. A review of literature was performed to identify common difficulties in recruiting older people. This in combination with our experience during recruitment for a randomized control trial, have highlighted numerous barriers. Population-specific recruitment strategies, simple informed-consent processes, and effective communication between the researcher and subject are effective strategies to overcome these barriers.
关于如何在临床试验中招募和保留老年人，相关信息有限。本综述的目的是确定在临床试验中招募老年人的常见障碍，并提出克服这些障碍的解决方案。对文献进行了回顾，以确定招募老年人的常见困难。这与我们在一项随机对照试验的招募过程中的经验相结合，突出了许多障碍。针对特定人群的招募策略、简单的知情同意程序以及研究人员和受试者之间的有效沟通，都是克服这些障碍的有效策略。
