Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Suite 401, Boston, MA 02114, USA.
Obstet Gynecol Clin North Am. 2009 Dec;36(4):789-807, x. doi: 10.1016/j.ogc.2009.10.005.
The popularity of natural or "alternative" remedies to treat medical and psychiatric disorders has accelerated dramatically over the past decade, in the United States and worldwide. This article reviews the evidence for clinical efficacy, active ingredients, mechanisms of action, recommended dosages, and toxicities of the 3 best-studied putative natural antidepressants, St. John's wort (hypericum), S-adenosyl methionine, and the Omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid. Despite growing evidence for efficacy and safety, more comprehensive studies are required before these remedies can be recommended as safe and effective alternatives or adjuncts to conventional psychotropic agents. There are limited data regarding safety in pregnancy and during lactation, and caution is therefore recommended in women who are pregnant or breastfeeding.
在过去的十年中，美国和全球范围内，人们对治疗医学和精神疾病的天然或“替代”疗法的兴趣急剧增加。本文综述了临床疗效、活性成分、作用机制、推荐剂量和毒性的证据，这 3 种研究最多的假定天然抗抑郁药，即贯叶连翘（金丝桃）、S-腺苷甲硫氨酸和欧米伽-3 脂肪酸二十碳五烯酸和二十二碳六烯酸。尽管有越来越多的疗效和安全性证据，但在这些疗法可以被推荐为安全有效的替代或辅助传统精神药物之前，还需要更全面的研究。关于妊娠和哺乳期安全性的数据有限，因此建议孕妇或哺乳期妇女慎用。
