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头颈部大容积调强放疗靶区的分割野与固定准直器技术的剂量学比较

Dosimetric comparison of split field and fixed jaw techniques for large IMRT target volumes in the head and neck.

作者信息

Srivastava Shiv P, Das Indra J, Kumar Arvind, Johnstone Peter A S

机构信息

Department of Radiation Oncology, Reid Hospital and Health Care Services Richmond, IN, USA.

出版信息

Med Dosim. 2011 Spring;36(1):6-9. doi: 10.1016/j.meddos.2009.10.002. Epub 2009 Nov 13.

Abstract

Some treatment planning systems (TPSs), when used for large-field (>14 cm) intensity-modulated radiation therapy (IMRT), create split fields that produce excessive multiple-leaf collimator segments, match-line dose inhomogeneity, and higher treatment times than nonsplit fields. A new method using a fixed-jaw technique (FJT) forces the jaw to stay at a fixed position during optimization and is proposed to reduce problems associated with split fields. Dosimetric comparisons between split-field technique (SFT) and FJT used for IMRT treatment is presented. Five patients with head and neck malignancies and regional target volumes were studied and compared with both techniques. Treatment planning was performed on an Eclipse TPS using beam data generated for Varian 2100C linear accelerator. A standard beam arrangement consisting of nine coplanar fields, equally spaced, was used in both techniques. Institutional dose-volume constraints used in head and neck cancer were kept the same for both techniques. The dosimetric coverage for the target volumes between SFT and FJT for head and neck IMRT plan is identical within ± 1% up to 90% dose. Similarly, the organs at risk (OARs) have dose-volume coverage nearly identical for all patients. When the total monitor unit (MU) and segments were analyzed, SFT produces statistically significant higher segments (17.3 ± 6.3%) and higher MU (13.7 ± 4.4%) than the FJT. There is no match line in FJT and hence dose uniformity in the target volume is superior to the SFT. Dosimetrically, SFT and FJT are similar for dose-volume coverage; however, the FJT method provides better logistics, lower MU, shorter treatment time, and better dose uniformity. The number of segments and MU also has been correlated with the whole body radiation dose with long-term complications. Thus, FJT should be the preferred option over SFT for large target volumes.

摘要

一些治疗计划系统(TPS)在用于大野(>14 cm)调强放射治疗(IMRT)时,会产生分割野,导致多叶准直器片段过多、匹配线剂量不均匀,且治疗时间比非分割野更长。一种使用固定钳口技术(FJT)的新方法可在优化过程中使钳口保持在固定位置,旨在减少与分割野相关的问题。本文展示了用于IMRT治疗的分割野技术(SFT)与FJT之间的剂量学比较。研究了5例头颈部恶性肿瘤及区域靶区体积的患者,并对两种技术进行了比较。使用为瓦里安2100C直线加速器生成的射束数据,在Eclipse TPS上进行治疗计划。两种技术均采用由9个共面野组成的标准射束排列,等间距分布。两种技术对头颈部癌使用的机构剂量体积约束保持相同。对于头颈部IMRT计划,SFT和FJT在靶区体积的剂量学覆盖方面,在高达90%剂量时,±1%范围内是相同的。同样,所有患者的危及器官(OAR)的剂量体积覆盖几乎相同。当分析总监测单位(MU)和片段时,SFT产生的片段数量(17.3±6.3%)和MU(13.7±4.4%)在统计学上显著高于FJT。FJT中不存在匹配线,因此靶区体积内的剂量均匀性优于SFT。在剂量体积覆盖方面,SFT和FJT在剂量学上相似;然而,FJT方法提供了更好的流程安排、更低的MU、更短的治疗时间和更好的剂量均匀性。片段数量和MU也与全身辐射剂量及长期并发症相关。因此,对于大靶区体积,FJT应是优于SFT的首选方案。

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